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• W1987145100 abstract "<i >Aim</i>. The purpose of this study was to evaluate the accuracy of 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET), computed tomography (CT), and software-based image fusion of both modalities in the imaging of non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). <i >Methods</i>. 77 patients with NHL (<svg style=vertical-align:-0.17555pt;width:42.912498px; id=M1 height=11.1 version=1.1 viewBox=0 0 42.912498 11.1 width=42.912498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.1)> <g transform=translate(72,-63.12)> <text transform=matrix(1,0,0,-1,-71.95,63.35)> <tspan style=font-size: 12.50px; x=0 y=0>𝑛</tspan> <tspan style=font-size: 12.50px; x=9.6773224 y=0>=</tspan> <tspan style=font-size: 12.50px; x=21.71771 y=0>5</tspan> <tspan style=font-size: 12.50px; x=27.969212 y=0>8</tspan> </text> </g> </g> </svg>) or HD (<svg style=vertical-align:-0.27588pt;width:42.912498px; id=M2 height=11.0375 version=1.1 viewBox=0 0 42.912498 11.0375 width=42.912498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.0375)> <g transform=translate(72,-63.17)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑛</tspan> <tspan style=font-size: 12.50px; x=9.6773224 y=0>=</tspan> <tspan style=font-size: 12.50px; x=21.71771 y=0>1</tspan> <tspan style=font-size: 12.50px; x=27.969212 y=0>9</tspan> </text> </g> </g> </svg>) underwent a FDG PET scan, a contrast-enhanced CT, and a subsequent digital image fusion during initial staging or followup. 109 examinations of each modality were evaluated and compared to each other. Conventional staging procedures, other imaging techniques, laboratory screening, and follow-up data constituted the reference standard for comparison with image fusion. Sensitivity and specificity were calculated for CT and PET separately. <i >Results</i>. Sensitivity and specificity for detecting malignant lymphoma were 90&#x25; and 76&#x25; for CT and 94&#x25; and 91&#x25; for PET, respectively. A lymph node region-based analysis (comprising 14 defined anatomical regions) revealed a sensitivity of 81&#x25; and a specificity of 97&#x25; for CT and 96&#x25; and 99&#x25; for FDG PET, respectively. Only three of 109 image fusion findings needed further evaluation (false positive). <i >Conclusion</i>. Digital fusion of PET and CT improves the accuracy of staging, restaging, and therapy monitoring in patients with malignant lymphoma and may reduce the need for invasive diagnostic procedures." @default.
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• W1987145100 date "2012-01-01" @default.
• W1987145100 modified "2023-09-27" @default.
• W1987145100 title "Diagnostic Value of Software-Based Image Fusion of Computed Tomography and F18-FDG PET Scans in Patients with Malignant Lymphoma" @default.
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• W1987145100 doi "https://doi.org/10.1100/2012/821694" @default.
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