Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987149198> ?p ?o ?g. }
- W1987149198 abstract "The protective effect of l-cis-diltiazem, the stereoisomer of d-cis-diltiazem, was studied against the veratridine-induced hypercontracture of rat myocytes. Veratridine increased both [Na+]i and [Ca2+]i, but did not cause hypercontracture in the absence of extracellular Ca2+. Both l-cis-diltiazem (0.1-10 microM) and d-cis-diltiazem (10-30 microM) inhibited the hypercontracture and the increase in [Ca2+]i in a concentration-dependent manner. However, l-cis-diltiazem did not exert a negative inotropic effect in K+ (20 mM)-depolarized rat papillary muscles even at a dose of 10 microM. As seen in the case of tetrodotoxin, l-cis-diltiazem and d-cis-diltiazem also suppressed the increase in [Na+]i. The results show that l-cis-diltiazem prevents the veratridine-induced hypercontracture of myocytes by suppression of the [Ca2+]i increase. The attenuation of the [Ca2+]i increase by l-cis-diltiazem was not dependent on inhibition of Ca2+ channels, but was partly due to inhibition of excessive Na+ entry via veratridine-modified Na+ channels." @default.
- W1987149198 created "2016-06-24" @default.
- W1987149198 creator A5032335582 @default.
- W1987149198 creator A5034124786 @default.
- W1987149198 creator A5044021682 @default.
- W1987149198 creator A5051610573 @default.
- W1987149198 date "1996-12-01" @default.
- W1987149198 modified "2023-09-25" @default.
- W1987149198 title "Protective effect of l-cis-diltiazem on hypercontracture of rat myocytes induced by veratridine" @default.
- W1987149198 cites W1496064460 @default.
- W1987149198 cites W1562324545 @default.
- W1987149198 cites W1577379996 @default.
- W1987149198 cites W1787646291 @default.
- W1987149198 cites W1883435193 @default.
- W1987149198 cites W1899895782 @default.
- W1987149198 cites W1967233060 @default.
- W1987149198 cites W1984510165 @default.
- W1987149198 cites W1984876837 @default.
- W1987149198 cites W2029778136 @default.
- W1987149198 cites W2034084412 @default.
- W1987149198 cites W2037032916 @default.
- W1987149198 cites W2044281531 @default.
- W1987149198 cites W2047563687 @default.
- W1987149198 cites W2048761153 @default.
- W1987149198 cites W2055531039 @default.
- W1987149198 cites W2089135808 @default.
- W1987149198 cites W2091051297 @default.
- W1987149198 cites W2093273130 @default.
- W1987149198 cites W2094620717 @default.
- W1987149198 cites W2099982099 @default.
- W1987149198 cites W2114460773 @default.
- W1987149198 cites W2153212195 @default.
- W1987149198 cites W2161607654 @default.
- W1987149198 cites W2229149116 @default.
- W1987149198 cites W2262660046 @default.
- W1987149198 cites W2306322519 @default.
- W1987149198 cites W2315513503 @default.
- W1987149198 cites W2414789701 @default.
- W1987149198 cites W2467689271 @default.
- W1987149198 cites W2472783997 @default.
- W1987149198 doi "https://doi.org/10.1016/s0014-2999(96)00758-3" @default.
- W1987149198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8997627" @default.
- W1987149198 hasPublicationYear "1996" @default.
- W1987149198 type Work @default.
- W1987149198 sameAs 1987149198 @default.
- W1987149198 citedByCount "9" @default.
- W1987149198 crossrefType "journal-article" @default.
- W1987149198 hasAuthorship W1987149198A5032335582 @default.
- W1987149198 hasAuthorship W1987149198A5034124786 @default.
- W1987149198 hasAuthorship W1987149198A5044021682 @default.
- W1987149198 hasAuthorship W1987149198A5051610573 @default.
- W1987149198 hasConcept C12554922 @default.
- W1987149198 hasConcept C134018914 @default.
- W1987149198 hasConcept C178790620 @default.
- W1987149198 hasConcept C185592680 @default.
- W1987149198 hasConcept C207200792 @default.
- W1987149198 hasConcept C2776741139 @default.
- W1987149198 hasConcept C2776741303 @default.
- W1987149198 hasConcept C2776986425 @default.
- W1987149198 hasConcept C28406088 @default.
- W1987149198 hasConcept C50952357 @default.
- W1987149198 hasConcept C519063684 @default.
- W1987149198 hasConcept C537181965 @default.
- W1987149198 hasConcept C55493867 @default.
- W1987149198 hasConcept C71924100 @default.
- W1987149198 hasConcept C86803240 @default.
- W1987149198 hasConcept C98274493 @default.
- W1987149198 hasConceptScore W1987149198C12554922 @default.
- W1987149198 hasConceptScore W1987149198C134018914 @default.
- W1987149198 hasConceptScore W1987149198C178790620 @default.
- W1987149198 hasConceptScore W1987149198C185592680 @default.
- W1987149198 hasConceptScore W1987149198C207200792 @default.
- W1987149198 hasConceptScore W1987149198C2776741139 @default.
- W1987149198 hasConceptScore W1987149198C2776741303 @default.
- W1987149198 hasConceptScore W1987149198C2776986425 @default.
- W1987149198 hasConceptScore W1987149198C28406088 @default.
- W1987149198 hasConceptScore W1987149198C50952357 @default.
- W1987149198 hasConceptScore W1987149198C519063684 @default.
- W1987149198 hasConceptScore W1987149198C537181965 @default.
- W1987149198 hasConceptScore W1987149198C55493867 @default.
- W1987149198 hasConceptScore W1987149198C71924100 @default.
- W1987149198 hasConceptScore W1987149198C86803240 @default.
- W1987149198 hasConceptScore W1987149198C98274493 @default.
- W1987149198 hasLocation W19871491981 @default.
- W1987149198 hasLocation W19871491982 @default.
- W1987149198 hasOpenAccess W1987149198 @default.
- W1987149198 hasPrimaryLocation W19871491981 @default.
- W1987149198 hasRelatedWork W1981888338 @default.
- W1987149198 hasRelatedWork W1987149198 @default.
- W1987149198 hasRelatedWork W1995707362 @default.
- W1987149198 hasRelatedWork W2020173902 @default.
- W1987149198 hasRelatedWork W2081911678 @default.
- W1987149198 hasRelatedWork W2084979309 @default.
- W1987149198 hasRelatedWork W2114958991 @default.
- W1987149198 hasRelatedWork W2341230731 @default.
- W1987149198 hasRelatedWork W2469394177 @default.
- W1987149198 hasRelatedWork W2491076412 @default.
- W1987149198 isParatext "false" @default.
- W1987149198 isRetracted "false" @default.
- W1987149198 magId "1987149198" @default.