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- W1987156789 endingPage "1143" @default.
- W1987156789 startingPage "1139" @default.
- W1987156789 abstract "1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other lifestyle-associated diseases has increased in relevance in Western societies in the past 100 years. 2. Traditionally, fat tissue has been considered as the major source of pro-inflammatory secreted factors in these pathologies. However, in recent years the contribution of other tissues to disease-causing chronic inflammation has been increasingly appreciated. 3. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is one of the key regulatory factors in active skeletal muscle. Aberrant expression of PGC-1α in inactive muscle fibres could be linked to a sedentary lifestyle, persistent systemic inflammation and a higher risk for many chronic diseases. Accordingly, modulation of PGC-1α activity in skeletal muscle may have a broad range of therapeutic effects. Here, recent advances in the understanding of the role of muscle PGC-1α in health and disease are reviewed." @default.
- W1987156789 created "2016-06-24" @default.
- W1987156789 creator A5021236744 @default.
- W1987156789 date "2009-12-01" @default.
- W1987156789 modified "2023-10-13" @default.
- W1987156789 title "Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation" @default.
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- W1987156789 doi "https://doi.org/10.1111/j.1440-1681.2009.05275.x" @default.
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