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- W1987157275 abstract "The development of concepts on the molecular mechanisms of the action of medicinal drugs on the opioid receptors is briefly surveyed. The modern point of view on the mechanism of activation of opioid receptors is given based on the data from chimeric and site-directed mutagenesis of the cloned opioid receptors and the computer-aided simulations of the reception zone and ligand–receptor complexes. Three-dimensional models of the opioid pharmacophore derived by both conventional methods and a comparative analysis of molecular fields are described in detail." @default.
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- W1987157275 date "2011-02-28" @default.
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- W1987157275 title "Development of concepts on the interaction of drugs with opioid receptors" @default.
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- W1987157275 doi "https://doi.org/10.1070/rc2011v080n02abeh004171" @default.
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