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- W1987161730 abstract "Human experimental pain models require standardized stimulation and quantitative assessment of the evoked responses. This approach can be applied to healthy volunteers and pain patients before and after pharmacological interventions. Standardized stimuli of different modalities (mechanical, chemical, thermal, electrical) can be applied to skin, muscles and viscera for a differentiated and comprehensive assessment of various pain pathways and mechanisms. Using such a multi-modal, multi-tissue approach, new and existing analgesic drugs can be profiled. Human experimental pain models can bridge animal and clinical pain research and act as translational research providing new possibilities for designing successful clinical trials. Proof-of-concept studies provide cheap, fast and reliable information about dose-efficacy relationships and how pain from skin, muscles and viscera are inhibited. This is important knowledge to have prior to designing expensive clinical trials." @default.
- W1987161730 created "2016-06-24" @default.
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- W1987161730 date "2007-09-01" @default.
- W1987161730 modified "2023-09-25" @default.
- W1987161730 title "Translational human pain research" @default.
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- W1987161730 doi "https://doi.org/10.1016/s1754-3207(08)60010-3" @default.
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