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- W1987165120 abstract "Growth factor stimulations induce dynamic changes in the cytoskeleton beneath the plasma membrane. Among them is the formation of membrane ruffles organized in a circular array, called 'circular dorsal ruffles' (CDRs). Physiological functions of CDRs include downregulation of cell growth by desensitizing the signalling from growth factor receptors as well as rearrangement of adhesion sites at the onset of cell migration. For the formation of CDRs, not only the activators of actin polymerization, such as N-WASP and the Arp2/3-complex, but also membrane deforming proteins with BAR/F-BAR domains are necessary. Small GTPases are also involved in the formation of CDRs by controlling intracellular trafficking through endosomes. Moreover, recent analyses of another circular cytoskeletal structure, podosome rosettes, have revealed common molecular features shared with CDRs. Among them, the roles of PI3-kinase and phosphoinositide 5-phosphatase may hold the key to the induction of these circular structures." @default.
- W1987165120 created "2016-06-24" @default.
- W1987165120 creator A5063537259 @default.
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- W1987165120 date "2012-11-21" @default.
- W1987165120 modified "2023-10-13" @default.
- W1987165120 title "Mechanistic insights into the regulation of circular dorsal ruffle formation" @default.
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- W1987165120 doi "https://doi.org/10.1093/jb/mvs138" @default.
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