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- W1987166671 abstract "The mitogen–activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood. In this study, we investigated the possible contribution of signaling pathways through c-Jun in platelet-derived growth factor (PDGF)-BB directed cell migration in rat aortic vascular smooth muscle cells (VSMCs) infected with a recombinant adenovirus containing the dominant-negative c-Jun (Ad-DN-c-Jun). DN-c-Jun protein was expressed dose-dependently in VSMCs infected with Ad-DN-c-Jun. Expression of DN-c-Jun significantly inhibited VSMC migration induced by PDGF-BB. Our results provide the first evidence that signaling pathways through c-Jun participates in cell migration induced by PDGF-BB in addition to other MAP kinase pathways in VSMCs." @default.
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- W1987166671 date "2003-01-01" @default.
- W1987166671 modified "2023-09-23" @default.
- W1987166671 title "Dominant Negative c-Jun Inhibits Platelet-Derived Growth Factor-Directed Migration by Vascular Smooth Muscle Cells" @default.
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- W1987166671 doi "https://doi.org/10.1254/jphs.91.145" @default.
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