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- W1987169706 abstract "Abstract 4 chlorinated hydrocarbon pesticides—chlordane, lindane, DDT and dicofol (Kelthane)—tested on tissue homogenates inhibited both the Na+-K+ ATPase and Mg2+ ATPase enzyme systems. Discrete fractions were obtained by differential and density-gradient centrifugation of tissue homogenates from rabbits, chickens, lake trout, and cockroaches; they included red blood cells, brain, olfactory, kidney, heart, liver and muscle. At low concentrations DDT was the most effective inhibitor of the Mg2+ ATPase. At higher concentrations, Kelthane produced the greatest inhibition of both ATPase activities. Chlordane and lindane also inhibited both ATPases with the former being the more effective. Red blood cell “ghosts” (plasma membranes) differed from other tissues in that its Na+-K+ ATPase activity was insensitive to the insecticides, except for a slight effect from Kelthane. The Mg2+ ATPase activity of a muscle fraction B from different sources was significantly more affected by the pesticides than that of a liver fraction B." @default.
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- W1987169706 date "1969-12-01" @default.
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- W1987169706 title "Inhibition of animal tissue ATPase activities by chlorinated hydrocarbon pesticides." @default.
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- W1987169706 doi "https://doi.org/10.1016/0009-2797(69)90007-6" @default.
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