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- W1987173897 abstract "The recommended maintenance dosage interval for digoxin in infants and children is 12 hours] ,2 whereas in adults the drug is administered once daily. Because target trough and peak values in children do not differ from those in adults, and because elimination half-life.is not shorter, it is not clear why digoxin should be administered twice daily. On the basis of available studies, the elimination half-life of digoxin averages between 20 hours in infants and up to 40 hours in children. 3-5 In our study, we compared serum concentrations and clinical observations in infants and children during once-daily and twice-daily administration of the cardiac glycoside." @default.
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- W1987173897 date "1990-01-01" @default.
- W1987173897 modified "2023-09-23" @default.
- W1987173897 title "Once-daily versus twice-daily dosing of digoxin in the pediatric age group" @default.
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- W1987173897 doi "https://doi.org/10.1016/s0022-3476(05)81665-8" @default.
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