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• W1987186486 abstract "Sensitizing and neurotoxic effect of ornidazole, was tested in a double-blind randomized study in patients with carcinoma of the cervix and larynx. Ornidazole or placebo were given orally, two times weekly, for 3 weeks. Dose was 2.5 g/m2 for each administration. Total dose given was 15 g/m2. Radiation therapy was given 3 h after the drug administration. Ornidazole was well tolerated in the majority of the patients. No neurotoxic side effects, such as peripheral neuropathy or convulsion, were observed with a total dose of up to 30 g. Dizziness, somnolence and nausea were the prominent acute side effects, seen mostly (70%) in women. In the placebo group this rate was 17% (p<0.01). No important side effect was observed in men receiving ornidazole. Serum concentration of ornidazole reached the maximum level in 2–4 h after oral administration and ranged (23 patients) from 65.1 to 139.8 μg/ml. Mean half-life was 15.6±2.8 h. Peak concentration in tumour tissue was achieved 1–3 h after the administration, ranging from 13.0 to 78.0 μg/g. Tumour concentration of ornidazole ranged from 14 to 93% of the serum concentration at the time of irradiation." @default.
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• W1987186486 date "1986-01-01" @default.
• W1987186486 modified "2023-09-27" @default.
• W1987186486 title "Use of ornidazole in fractionated radiotherapy: Dose tolerance, serum and tumour tissue concentration" @default.
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• W1987186486 doi "https://doi.org/10.1016/s0167-8140(86)80178-5" @default.
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