FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987190223> ?p ?o ?g. }

• W1987190223 endingPage "429" @default.
• W1987190223 startingPage "422" @default.
• W1987190223 abstract "Epidermal growth factor (EGF) induces rapid rounding of A-431 human epidermoid carcinoma cells in Ca(++)-free medium. Cell rounding is not induced by a variety of other polypeptide hormones, antiserum to cell membranes, local anesthetics, colchicine, cytochalasin B, or cyclic nucleotides. However, trypsin, like EGF, induces rounding of A- 431 cells in the absence of Ca(++). Both trypsin- and EGF-induced rounding are temperature dependent, appear to be energy dependent, and are inhibited by cytochalasins, suggesting that the active participation of microfilaments in cell rounding. However, a medium transfer experiment suggests that EGF-induced rounding is not attributable to secretion of a protease, and a number of serine protease inhibitors have no effect on the EGF-induced rounding process. Cell rounding is not attributable to the slight stimulation by EGF of the release of Ca(++) that is observed in the Ca(++)-free medium, as stimulation of such release by the ionophore A23187 neither induces cell rounding nor blocks EGF-induced rounding. Cells that have rounded up after treatment with EGF or trypsin spread out upon addition of Ca(++) to the medium, even in the continuing presence of EGF or typsin. Like the cell-rounding process, the cell-spreading process is temperature dependent, appears to be energy dependent, and is inhibited by cytochalasin B. Thus, EGF does not destroy the ability of the cell to spread; rather, in the presence of the EGF (or trypsin), cell spreading and the maintenance of the flattened state become dependent on external Ca(++). Because untreated cells remain flattened in the absence of Ca(++), the data suggest that EGF may disrupt Ca(++)-independent mechanisms of adhesion normally present in A-431 cells." @default.
• W1987190223 created "2016-06-24" @default.
• W1987190223 creator A5010238664 @default.
• W1987190223 creator A5065192683 @default.
• W1987190223 creator A5082827854 @default.
• W1987190223 date "1981-02-01" @default.
• W1987190223 modified "2023-10-14" @default.
• W1987190223 title "Rapid rounding of human epidermoid carcinoma cells A-431 induced by epidermal growth factor" @default.
• W1987190223 cites W1428637608 @default.
• W1987190223 cites W1498071142 @default.
• W1987190223 cites W1501383613 @default.
• W1987190223 cites W1522098040 @default.
• W1987190223 cites W1524333424 @default.
• W1987190223 cites W1565936547 @default.
• W1987190223 cites W1969831036 @default.
• W1987190223 cites W1973056000 @default.
• W1987190223 cites W1991934454 @default.
• W1987190223 cites W1992250994 @default.
• W1987190223 cites W1999815907 @default.
• W1987190223 cites W2002681855 @default.
• W1987190223 cites W2007719101 @default.
• W1987190223 cites W2011147958 @default.
• W1987190223 cites W2015175431 @default.
• W1987190223 cites W2016998343 @default.
• W1987190223 cites W2017813247 @default.
• W1987190223 cites W2017919338 @default.
• W1987190223 cites W2023789752 @default.
• W1987190223 cites W2029514086 @default.
• W1987190223 cites W2031994589 @default.
• W1987190223 cites W2036515689 @default.
• W1987190223 cites W2040469480 @default.
• W1987190223 cites W2043631234 @default.
• W1987190223 cites W2044240199 @default.
• W1987190223 cites W2046374440 @default.
• W1987190223 cites W2048169623 @default.
• W1987190223 cites W2062483982 @default.
• W1987190223 cites W2062745430 @default.
• W1987190223 cites W2063639703 @default.
• W1987190223 cites W2064529356 @default.
• W1987190223 cites W2069161066 @default.
• W1987190223 cites W2071599698 @default.
• W1987190223 cites W2089144568 @default.
• W1987190223 cites W2093479997 @default.
• W1987190223 cites W2099335992 @default.
• W1987190223 cites W2109006351 @default.
• W1987190223 cites W2145858875 @default.
• W1987190223 cites W220382598 @default.
• W1987190223 cites W90038575 @default.
• W1987190223 doi "https://doi.org/10.1083/jcb.88.2.422" @default.
• W1987190223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2111751" @default.
• W1987190223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6259180" @default.
• W1987190223 hasPublicationYear "1981" @default.
• W1987190223 type Work @default.
• W1987190223 sameAs 1987190223 @default.
• W1987190223 citedByCount "130" @default.
• W1987190223 countsByYear W19871902232012 @default.
• W1987190223 countsByYear W19871902232014 @default.
• W1987190223 countsByYear W19871902232016 @default.
• W1987190223 countsByYear W19871902232018 @default.
• W1987190223 countsByYear W19871902232021 @default.
• W1987190223 crossrefType "journal-article" @default.
• W1987190223 hasAuthorship W1987190223A5010238664 @default.
• W1987190223 hasAuthorship W1987190223A5065192683 @default.
• W1987190223 hasAuthorship W1987190223A5082827854 @default.
• W1987190223 hasBestOaLocation W19871902231 @default.
• W1987190223 hasConcept C111919701 @default.
• W1987190223 hasConcept C121608353 @default.
• W1987190223 hasConcept C136625980 @default.
• W1987190223 hasConcept C142669718 @default.
• W1987190223 hasConcept C1491633281 @default.
• W1987190223 hasConcept C153911025 @default.
• W1987190223 hasConcept C181199279 @default.
• W1987190223 hasConcept C2775995422 @default.
• W1987190223 hasConcept C2776362946 @default.
• W1987190223 hasConcept C2779012151 @default.
• W1987190223 hasConcept C2780340462 @default.
• W1987190223 hasConcept C2994460389 @default.
• W1987190223 hasConcept C41008148 @default.
• W1987190223 hasConcept C54355233 @default.
• W1987190223 hasConcept C55493867 @default.
• W1987190223 hasConcept C81885089 @default.
• W1987190223 hasConcept C86803240 @default.
• W1987190223 hasConcept C95444343 @default.
• W1987190223 hasConceptScore W1987190223C111919701 @default.
• W1987190223 hasConceptScore W1987190223C121608353 @default.
• W1987190223 hasConceptScore W1987190223C136625980 @default.
• W1987190223 hasConceptScore W1987190223C142669718 @default.
• W1987190223 hasConceptScore W1987190223C1491633281 @default.
• W1987190223 hasConceptScore W1987190223C153911025 @default.
• W1987190223 hasConceptScore W1987190223C181199279 @default.
• W1987190223 hasConceptScore W1987190223C2775995422 @default.
• W1987190223 hasConceptScore W1987190223C2776362946 @default.
• W1987190223 hasConceptScore W1987190223C2779012151 @default.
• W1987190223 hasConceptScore W1987190223C2780340462 @default.
• W1987190223 hasConceptScore W1987190223C2994460389 @default.
• W1987190223 hasConceptScore W1987190223C41008148 @default.
• W1987190223 hasConceptScore W1987190223C54355233 @default.
• W1987190223 hasConceptScore W1987190223C55493867 @default.

• next