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• W19871922 endingPage "2076" @default.
• W19871922 startingPage "2065" @default.
• W19871922 abstract "Human amnion-derived cells are considered to be a promising alternative cell source for their potential clinical use in tissue engineering and regenerative medicine because of their proliferation and differentiation ability. The cells can easily be obtained from human amnion, offering a potential source without medical intervention. It has been proven that human amnion-derived cells express immunosuppressive factors CD59 and HLA-G, implying that they may have an immunosuppressive function. To assess the immunosuppressive activity, we investigated the effect of human amnion-derived cells on NK cell and monocyte function. Amnion-derived cells inhibited the cytotoxicity of NK cells to K562 cells. The inhibition depended on the NK/amnion-derived cell ratio. The inhibition of NK cytotoxicity was recovered by continuous culturing without amnion-derived cells. The inhibition of NK cytotoxicity was related to the downregulation of the expression of the activated NK receptors and the production of IFN-γ, as well as the upregulation of the expression of IL-10 and PGE 2 in human amnion-derived cells. The addition of antibody to IL-10 or PGE 2 inhibitor tended to increase NK cytotoxicity. IL-10 and PGE 2 might be involved in the immunosuppressive activity of amniotic cells toward NK cells. Amniotic cells also suppressed the activity of cytokine production in monocytes analyzed with TNF-α and IL-6. These data suggested that amniotic cells have immunosuppressive activity." @default.
• W19871922 created "2016-06-24" @default.
• W19871922 creator A5040981738 @default.
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• W19871922 date "2015-10-01" @default.
• W19871922 modified "2023-10-18" @default.
• W19871922 title "Human Amnion-Derived Stem Cells Have Immunosuppressive Properties on NK Cells and Monocytes" @default.
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• W19871922 doi "https://doi.org/10.3727/096368914x685230" @default.
• W19871922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25333453" @default.
• W19871922 hasPublicationYear "2015" @default.
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