FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987200107> ?p ?o ?g. }

• W1987200107 endingPage "631" @default.
• W1987200107 startingPage "627" @default.
• W1987200107 abstract "The gut microbiota is a complex ecosystem that has coevolved with host physiology. Colonization of germ-free (GF) mice with a microbiota promotes increased vessel density in the small intestine, but little is known about the mechanisms involved. Tissue factor (TF) is the membrane receptor that initiates the extrinsic coagulation pathway, and it promotes developmental and tumour angiogenesis. Here we show that the gut microbiota promotes TF glycosylation associated with localization of TF on the cell surface, the activation of coagulation proteases, and phosphorylation of the TF cytoplasmic domain in the small intestine. Anti-TF treatment of colonized GF mice decreased microbiota-induced vascular remodelling and expression of the proangiogenic factor angiopoietin-1 (Ang-1) in the small intestine. Mice with a genetic deletion of the TF cytoplasmic domain or with hypomorphic TF (F3) alleles had a decreased intestinal vessel density. Coagulation proteases downstream of TF activate protease-activated receptor (PAR) signalling implicated in angiogenesis. Vessel density and phosphorylation of the cytoplasmic domain of TF were decreased in small intestine from PAR1-deficient (F2r(-/-)) but not PAR2-deficient (F2rl1(-/-)) mice, and inhibition of thrombin showed that thrombin-PAR1 signalling was upstream of TF phosphorylation. Thus, the microbiota-induced extravascular TF-PAR1 signalling loop is a novel pathway that may be modulated to influence vascular remodelling in the small intestine." @default.
• W1987200107 created "2016-06-24" @default.
• W1987200107 creator A5005150806 @default.
• W1987200107 creator A5005286957 @default.
• W1987200107 creator A5017861039 @default.
• W1987200107 creator A5028627723 @default.
• W1987200107 creator A5047963662 @default.
• W1987200107 creator A5050874021 @default.
• W1987200107 creator A5061833208 @default.
• W1987200107 creator A5062413979 @default.
• W1987200107 date "2012-03-01" @default.
• W1987200107 modified "2023-10-14" @default.
• W1987200107 title "Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling" @default.
• W1987200107 cites W1513923768 @default.
• W1987200107 cites W1528445591 @default.
• W1987200107 cites W1537737962 @default.
• W1987200107 cites W1964456661 @default.
• W1987200107 cites W1974218755 @default.
• W1987200107 cites W1979266650 @default.
• W1987200107 cites W1985750263 @default.
• W1987200107 cites W1985975297 @default.
• W1987200107 cites W1990191742 @default.
• W1987200107 cites W1992496728 @default.
• W1987200107 cites W1995387334 @default.
• W1987200107 cites W1996430165 @default.
• W1987200107 cites W2014531495 @default.
• W1987200107 cites W2015912610 @default.
• W1987200107 cites W2019573005 @default.
• W1987200107 cites W2025136659 @default.
• W1987200107 cites W2038145396 @default.
• W1987200107 cites W2041327868 @default.
• W1987200107 cites W2050016905 @default.
• W1987200107 cites W2059834678 @default.
• W1987200107 cites W2066888615 @default.
• W1987200107 cites W2067033925 @default.
• W1987200107 cites W2068655393 @default.
• W1987200107 cites W2083403388 @default.
• W1987200107 cites W2101137688 @default.
• W1987200107 cites W2104890139 @default.
• W1987200107 cites W2133024684 @default.
• W1987200107 cites W2137907878 @default.
• W1987200107 cites W2139005650 @default.
• W1987200107 cites W2157930949 @default.
• W1987200107 cites W2169619812 @default.
• W1987200107 cites W2170640128 @default.
• W1987200107 doi "https://doi.org/10.1038/nature10893" @default.
• W1987200107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3885420" @default.
• W1987200107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22407318" @default.
• W1987200107 hasPublicationYear "2012" @default.
• W1987200107 type Work @default.
• W1987200107 sameAs 1987200107 @default.
• W1987200107 citedByCount "213" @default.
• W1987200107 countsByYear W19872001072012 @default.
• W1987200107 countsByYear W19872001072013 @default.
• W1987200107 countsByYear W19872001072014 @default.
• W1987200107 countsByYear W19872001072015 @default.
• W1987200107 countsByYear W19872001072016 @default.
• W1987200107 countsByYear W19872001072017 @default.
• W1987200107 countsByYear W19872001072018 @default.
• W1987200107 countsByYear W19872001072019 @default.
• W1987200107 countsByYear W19872001072020 @default.
• W1987200107 countsByYear W19872001072021 @default.
• W1987200107 countsByYear W19872001072022 @default.
• W1987200107 countsByYear W19872001072023 @default.
• W1987200107 crossrefType "journal-article" @default.
• W1987200107 hasAuthorship W1987200107A5005150806 @default.
• W1987200107 hasAuthorship W1987200107A5005286957 @default.
• W1987200107 hasAuthorship W1987200107A5017861039 @default.
• W1987200107 hasAuthorship W1987200107A5028627723 @default.
• W1987200107 hasAuthorship W1987200107A5047963662 @default.
• W1987200107 hasAuthorship W1987200107A5050874021 @default.
• W1987200107 hasAuthorship W1987200107A5061833208 @default.
• W1987200107 hasAuthorship W1987200107A5062413979 @default.
• W1987200107 hasBestOaLocation W19872001072 @default.
• W1987200107 hasConcept C11960822 @default.
• W1987200107 hasConcept C126322002 @default.
• W1987200107 hasConcept C170493617 @default.
• W1987200107 hasConcept C181199279 @default.
• W1987200107 hasConcept C182220744 @default.
• W1987200107 hasConcept C186738567 @default.
• W1987200107 hasConcept C203014093 @default.
• W1987200107 hasConcept C2777292125 @default.
• W1987200107 hasConcept C2778382381 @default.
• W1987200107 hasConcept C2780394083 @default.
• W1987200107 hasConcept C502942594 @default.
• W1987200107 hasConcept C55493867 @default.
• W1987200107 hasConcept C71924100 @default.
• W1987200107 hasConcept C86803240 @default.
• W1987200107 hasConcept C89560881 @default.
• W1987200107 hasConcept C95444343 @default.
• W1987200107 hasConceptScore W1987200107C11960822 @default.
• W1987200107 hasConceptScore W1987200107C126322002 @default.
• W1987200107 hasConceptScore W1987200107C170493617 @default.
• W1987200107 hasConceptScore W1987200107C181199279 @default.
• W1987200107 hasConceptScore W1987200107C182220744 @default.
• W1987200107 hasConceptScore W1987200107C186738567 @default.
• W1987200107 hasConceptScore W1987200107C203014093 @default.
• W1987200107 hasConceptScore W1987200107C2777292125 @default.

• next