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- W1987201104 abstract "As a very important transcription factor, signal transducer and activator of transcription 5a (Stat5a) has been reported to be involved in human reproductive cancers such as breast, prostate and ovarian cancer. However, up to date, the exact role of Stat5a in breast cancer is still not clear. The data reported are conflicting. D5 Stat5a is a variant of Stat5a we cloned previously. In the present study, we examined its effect on the migration of cultured breast cancer cells (MCF-7) by using adenovirus-mediated gene transfer and transwell technology. Also, chromatin immunoprecipitation (ChIP) assay and quantitative real time polymerase chain reaction (qRT-PCR) were applied to probe to epigenetic changes with overexpression of this newly cloned variant. The results showed that D5 Stat5a behave very differently from its full length counterpart, Stat5a, in cell migration of breast cancer cells. Stat5a inhibits, but D5 Stat5a promotes the migration of breast cancer cells. ChIP and qRT-PCR evidenced that overexpression of this variant increased trimethylation of lysine 27 on histone 3 (H3K27Me3) of E-Cadherin promoter region. The new form of Stat5a and the results of the present study may account for, at least partly, the conflict phenomenon reported by different investigators regarding the role of Stat5a in reproductive cancer." @default.
- W1987201104 created "2016-06-24" @default.
- W1987201104 creator A5032374386 @default.
- W1987201104 date "2013-12-31" @default.
- W1987201104 modified "2023-10-18" @default.
- W1987201104 title "Association of D5 Stat5a Induced Breast Cancer Cell Migration with Increased H3K27 Trimethylation and Down-Regulated Expression of E-Cadherin Gene" @default.
- W1987201104 doi "https://doi.org/10.4247/am.2013.abd066" @default.
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