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• W1987202419 endingPage "59" @default.
• W1987202419 startingPage "43" @default.
• W1987202419 abstract "The murine cytomegalovirus (MCMV) M44 gene product pp50 is normally present in the nuclei of virus-infected cells. During transient expression of pp50 in COS-1 cells, the phosphoprotein was readily detectable in the nuclei, indicating that it possesses a nuclear localization signal (NLS). Studies on the subcellular locations of N- and C-terminal deletion mutants of pp50 suggested that alterations in both the C terminus and the highly conserved N-terminal domains of pp50 affect nuclear localization. In particular, the C-terminal 11 amino acids of pp50, which includes a KKQK motif, were able to mediate the import of a beta-galactosidase fusion protein into the nucleus. The pair of lysine residues in this motif constitutes an essential element of the C-terminal NLS as mutation of this motif to AAQK directly affected the nuclear localization of either pp50 or beta-galactosidase fusion proteins containing the C-terminal portion of pp50. Furthermore our results indicated that the functionality of the C-terminal NLS is dependent on the structural integrity of the highly conserved N-terminal portion of the molecule, as deletion of amino acids 157-201 alone adversely affected nuclear localization. In the absence of a functional C-terminal NLS, the subcellular localization of pp50 is sensitive to potential conformational changes induced by mutations within the N-terminal half of the molecule. Under those circumstances, mutation of the YK residues at position 22-23 or deletion of amino acids 267-283 was sufficient to produce a protein that was impaired in nuclear import or retention." @default.
• W1987202419 created "2016-06-24" @default.
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• W1987202419 creator A5047233621 @default.
• W1987202419 date "1999-06-01" @default.
• W1987202419 modified "2023-10-09" @default.
• W1987202419 title "Sequence Requirements for the Nuclear Localization of the Murine Cytomegalovirus M44 Gene Product pp50" @default.
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• W1987202419 doi "https://doi.org/10.1006/viro.1999.9700" @default.
• W1987202419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10364488" @default.
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