Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987204966> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1987204966 endingPage "309" @default.
- W1987204966 startingPage "301" @default.
- W1987204966 abstract "We wanted to analyse the binding mode of small anion inhibitors to the zinc enzyme carbonic anhydrase in order to explore the binding of substrates and the catalytic mechanism of the enzyme. This was started by recording two data-sets by Laue diffraction to obtain the wanted structural information. In addition we wanted to test the capacity of the Laue method to show the small structural changes that are often associated with the catalytic activity of m any enzymes. To be able to exploit fully time-resolved crystallography the method should be able to detect such minor structural changes. The obtained Laue results did not agree with the expected molecular structures. Thus we needed to record monochromatic data-sets of the same states of the enzyme to confirm our results. All major findings from the Laue data agree with the monochromatic data. Stimulated by the unexpected findings we have continued the investigations of anion binding to carbonic anhydrase. We have studied both the zinc enzyme and replaced the native metal by cobalt which also yields an active enzyme. The accumulated picture of the ligand binding to the enzyme sheds new light on the substrate binding and on the catalytic mechanism." @default.
- W1987204966 created "2016-06-24" @default.
- W1987204966 creator A5006336941 @default.
- W1987204966 creator A5016993515 @default.
- W1987204966 creator A5070806524 @default.
- W1987204966 creator A5080591106 @default.
- W1987204966 creator A5080894570 @default.
- W1987204966 creator A5081141506 @default.
- W1987204966 date "1992-08-15" @default.
- W1987204966 modified "2023-09-24" @default.
- W1987204966 title "Laue and monochromatic crystallography on carbonic anhydrase" @default.
- W1987204966 cites W1965648605 @default.
- W1987204966 cites W1975818527 @default.
- W1987204966 cites W2000881453 @default.
- W1987204966 cites W2012506672 @default.
- W1987204966 cites W2013083986 @default.
- W1987204966 cites W2015919894 @default.
- W1987204966 cites W2024535919 @default.
- W1987204966 cites W2042987185 @default.
- W1987204966 cites W2045246283 @default.
- W1987204966 cites W2065717154 @default.
- W1987204966 cites W2100224938 @default.
- W1987204966 cites W2153023761 @default.
- W1987204966 cites W2238928746 @default.
- W1987204966 doi "https://doi.org/10.1098/rsta.1992.0068" @default.
- W1987204966 hasPublicationYear "1992" @default.
- W1987204966 type Work @default.
- W1987204966 sameAs 1987204966 @default.
- W1987204966 citedByCount "4" @default.
- W1987204966 crossrefType "journal-article" @default.
- W1987204966 hasAuthorship W1987204966A5006336941 @default.
- W1987204966 hasAuthorship W1987204966A5016993515 @default.
- W1987204966 hasAuthorship W1987204966A5070806524 @default.
- W1987204966 hasAuthorship W1987204966A5080591106 @default.
- W1987204966 hasAuthorship W1987204966A5080894570 @default.
- W1987204966 hasAuthorship W1987204966A5081141506 @default.
- W1987204966 hasConcept C120665830 @default.
- W1987204966 hasConcept C121332964 @default.
- W1987204966 hasConcept C178790620 @default.
- W1987204966 hasConcept C181199279 @default.
- W1987204966 hasConcept C185592680 @default.
- W1987204966 hasConcept C207114421 @default.
- W1987204966 hasConcept C2775914622 @default.
- W1987204966 hasConcept C2780416268 @default.
- W1987204966 hasConcept C40833965 @default.
- W1987204966 hasConcept C41183919 @default.
- W1987204966 hasConcept C50515024 @default.
- W1987204966 hasConcept C535196362 @default.
- W1987204966 hasConcept C55493867 @default.
- W1987204966 hasConcept C71240020 @default.
- W1987204966 hasConcept C8010536 @default.
- W1987204966 hasConceptScore W1987204966C120665830 @default.
- W1987204966 hasConceptScore W1987204966C121332964 @default.
- W1987204966 hasConceptScore W1987204966C178790620 @default.
- W1987204966 hasConceptScore W1987204966C181199279 @default.
- W1987204966 hasConceptScore W1987204966C185592680 @default.
- W1987204966 hasConceptScore W1987204966C207114421 @default.
- W1987204966 hasConceptScore W1987204966C2775914622 @default.
- W1987204966 hasConceptScore W1987204966C2780416268 @default.
- W1987204966 hasConceptScore W1987204966C40833965 @default.
- W1987204966 hasConceptScore W1987204966C41183919 @default.
- W1987204966 hasConceptScore W1987204966C50515024 @default.
- W1987204966 hasConceptScore W1987204966C535196362 @default.
- W1987204966 hasConceptScore W1987204966C55493867 @default.
- W1987204966 hasConceptScore W1987204966C71240020 @default.
- W1987204966 hasConceptScore W1987204966C8010536 @default.
- W1987204966 hasIssue "1657" @default.
- W1987204966 hasLocation W19872049661 @default.
- W1987204966 hasOpenAccess W1987204966 @default.
- W1987204966 hasPrimaryLocation W19872049661 @default.
- W1987204966 hasRelatedWork W1883722763 @default.
- W1987204966 hasRelatedWork W1964914233 @default.
- W1987204966 hasRelatedWork W1971387475 @default.
- W1987204966 hasRelatedWork W1972992920 @default.
- W1987204966 hasRelatedWork W1987204966 @default.
- W1987204966 hasRelatedWork W2006699098 @default.
- W1987204966 hasRelatedWork W2018653067 @default.
- W1987204966 hasRelatedWork W2076435805 @default.
- W1987204966 hasRelatedWork W2902285912 @default.
- W1987204966 hasRelatedWork W2952804851 @default.
- W1987204966 hasVolume "340" @default.
- W1987204966 isParatext "false" @default.
- W1987204966 isRetracted "false" @default.
- W1987204966 magId "1987204966" @default.
- W1987204966 workType "article" @default.