FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987221489> ?p ?o ?g. }

• W1987221489 endingPage "1217" @default.
• W1987221489 startingPage "1210" @default.
• W1987221489 abstract "Tributyltin chloride (TBT-Cl) is an endocrine disruptor found in many animal species, and it is also known to be an inhibitor for the V-ATPases that are emerging as potential targets in the treatment of diseases such as osteoporosis and cancer. We demonstrated by using biochemical and single-molecular imaging techniques that TBT-Cl arrests an elementary step for rotary catalysis of the V1 motor domain. In the presence of TBT-Cl, the consecutive rotation of V1 paused for a long duration (∼0.5 s), even at saturated ATP concentrations, and the pausing positions were localized at 120° intervals. Analysis of both the pausing time and moving time revealed that TBT-Cl has little effect on the binding affinity for ATP, but, rather, it arrests the catalytic event(s). This is the first report to demonstrate that an inhibitor arrests an elementary step for rotary catalysis of a V-type ATP-driven rotary motor." @default.
• W1987221489 created "2016-06-24" @default.
• W1987221489 creator A5005069115 @default.
• W1987221489 creator A5023393050 @default.
• W1987221489 creator A5046936364 @default.
• W1987221489 creator A5073097263 @default.
• W1987221489 creator A5075508141 @default.
• W1987221489 date "2009-02-01" @default.
• W1987221489 modified "2023-10-14" @default.
• W1987221489 title "Mechanism of Inhibition of the V-Type Molecular Motor by Tributyltin Chloride" @default.
• W1987221489 cites W1553859523 @default.
• W1987221489 cites W1959675974 @default.
• W1987221489 cites W1967312776 @default.
• W1987221489 cites W1985026438 @default.
• W1987221489 cites W2013905125 @default.
• W1987221489 cites W2017587712 @default.
• W1987221489 cites W2026638965 @default.
• W1987221489 cites W2031522015 @default.
• W1987221489 cites W2033959706 @default.
• W1987221489 cites W2036871316 @default.
• W1987221489 cites W2044204709 @default.
• W1987221489 cites W2046585193 @default.
• W1987221489 cites W2047080468 @default.
• W1987221489 cites W2048296322 @default.
• W1987221489 cites W2051764674 @default.
• W1987221489 cites W2061720596 @default.
• W1987221489 cites W2067519531 @default.
• W1987221489 cites W2070744775 @default.
• W1987221489 cites W2074033410 @default.
• W1987221489 cites W2075332282 @default.
• W1987221489 cites W2077276444 @default.
• W1987221489 cites W2101123856 @default.
• W1987221489 cites W2113677196 @default.
• W1987221489 cites W2122367280 @default.
• W1987221489 cites W2129437247 @default.
• W1987221489 cites W2132483504 @default.
• W1987221489 cites W2134780839 @default.
• W1987221489 cites W2141960857 @default.
• W1987221489 cites W2167656141 @default.
• W1987221489 cites W53962561 @default.
• W1987221489 cites W906736390 @default.
• W1987221489 doi "https://doi.org/10.1016/j.bpj.2008.10.031" @default.
• W1987221489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2716569" @default.
• W1987221489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19186155" @default.
• W1987221489 hasPublicationYear "2009" @default.
• W1987221489 type Work @default.
• W1987221489 sameAs 1987221489 @default.
• W1987221489 citedByCount "12" @default.
• W1987221489 countsByYear W19872214892012 @default.
• W1987221489 countsByYear W19872214892013 @default.
• W1987221489 countsByYear W19872214892014 @default.
• W1987221489 countsByYear W19872214892015 @default.
• W1987221489 countsByYear W19872214892016 @default.
• W1987221489 countsByYear W19872214892022 @default.
• W1987221489 crossrefType "journal-article" @default.
• W1987221489 hasAuthorship W1987221489A5005069115 @default.
• W1987221489 hasAuthorship W1987221489A5023393050 @default.
• W1987221489 hasAuthorship W1987221489A5046936364 @default.
• W1987221489 hasAuthorship W1987221489A5073097263 @default.
• W1987221489 hasAuthorship W1987221489A5075508141 @default.
• W1987221489 hasBestOaLocation W19872214891 @default.
• W1987221489 hasConcept C107872376 @default.
• W1987221489 hasConcept C121332964 @default.
• W1987221489 hasConcept C12554922 @default.
• W1987221489 hasConcept C160408235 @default.
• W1987221489 hasConcept C161790260 @default.
• W1987221489 hasConcept C178790620 @default.
• W1987221489 hasConcept C181199279 @default.
• W1987221489 hasConcept C185592680 @default.
• W1987221489 hasConcept C23265538 @default.
• W1987221489 hasConcept C2778695967 @default.
• W1987221489 hasConcept C2779078112 @default.
• W1987221489 hasConcept C2780862370 @default.
• W1987221489 hasConcept C46699223 @default.
• W1987221489 hasConcept C55493867 @default.
• W1987221489 hasConcept C62520636 @default.
• W1987221489 hasConcept C71240020 @default.
• W1987221489 hasConcept C71315377 @default.
• W1987221489 hasConcept C86803240 @default.
• W1987221489 hasConcept C89611455 @default.
• W1987221489 hasConceptScore W1987221489C107872376 @default.
• W1987221489 hasConceptScore W1987221489C121332964 @default.
• W1987221489 hasConceptScore W1987221489C12554922 @default.
• W1987221489 hasConceptScore W1987221489C160408235 @default.
• W1987221489 hasConceptScore W1987221489C161790260 @default.
• W1987221489 hasConceptScore W1987221489C178790620 @default.
• W1987221489 hasConceptScore W1987221489C181199279 @default.
• W1987221489 hasConceptScore W1987221489C185592680 @default.
• W1987221489 hasConceptScore W1987221489C23265538 @default.
• W1987221489 hasConceptScore W1987221489C2778695967 @default.
• W1987221489 hasConceptScore W1987221489C2779078112 @default.
• W1987221489 hasConceptScore W1987221489C2780862370 @default.
• W1987221489 hasConceptScore W1987221489C46699223 @default.
• W1987221489 hasConceptScore W1987221489C55493867 @default.
• W1987221489 hasConceptScore W1987221489C62520636 @default.
• W1987221489 hasConceptScore W1987221489C71240020 @default.
• W1987221489 hasConceptScore W1987221489C71315377 @default.
• W1987221489 hasConceptScore W1987221489C86803240 @default.

• next