FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987225239> ?p ?o ?g. }

• W1987225239 endingPage "805" @default.
• W1987225239 startingPage "790" @default.
• W1987225239 abstract "Bidirectional synaptic plasticity occurs locally at individual synapses during long-term potentiation (LTP) or long-term depression (LTD), or globally during homeostatic scaling. LTP, LTD, and homeostatic scaling alter synaptic strength through changes in postsynaptic AMPA-type glutamate receptors (AMPARs), suggesting the existence of overlapping molecular mechanisms. Phosphorylation controls AMPAR trafficking during LTP/LTD. We addressed the role of AMPAR phosphorylation during homeostatic scaling. We observed bidirectional changes of the levels of phosphorylated GluA1 S845 during scaling, resulting from a loss of protein kinase A (PKA) from synapses during scaling down and enhanced activity of PKA in synapses during scaling up. Increased phosphorylation of S845 drove scaling up, while a knockin mutation of S845, or knockdown of the scaffold AKAP5, blocked scaling up. Finally, we show that AMPARs scale differentially based on their phosphorylation status at S845. These results show that rearrangement in PKA signaling controls AMPAR phosphorylation and surface targeting during homeostatic plasticity." @default.
• W1987225239 created "2016-06-24" @default.
• W1987225239 creator A5059601597 @default.
• W1987225239 creator A5065713713 @default.
• W1987225239 creator A5081849997 @default.
• W1987225239 date "2014-11-01" @default.
• W1987225239 modified "2023-10-01" @default.
• W1987225239 title "PKA-GluA1 Coupling via AKAP5 Controls AMPA Receptor Phosphorylation and Cell-Surface Targeting during Bidirectional Homeostatic Plasticity" @default.
• W1987225239 cites W1514853588 @default.
• W1987225239 cites W1609834322 @default.
• W1987225239 cites W1805816820 @default.
• W1987225239 cites W1929828037 @default.
• W1987225239 cites W1964330366 @default.
• W1987225239 cites W1969507049 @default.
• W1987225239 cites W1978155331 @default.
• W1987225239 cites W1983252720 @default.
• W1987225239 cites W1993135690 @default.
• W1987225239 cites W1993536619 @default.
• W1987225239 cites W2003981789 @default.
• W1987225239 cites W2015144766 @default.
• W1987225239 cites W2016126067 @default.
• W1987225239 cites W2016575029 @default.
• W1987225239 cites W2021088263 @default.
• W1987225239 cites W2027436298 @default.
• W1987225239 cites W2035082265 @default.
• W1987225239 cites W2038001775 @default.
• W1987225239 cites W2045780885 @default.
• W1987225239 cites W2047535883 @default.
• W1987225239 cites W2050066016 @default.
• W1987225239 cites W2050187823 @default.
• W1987225239 cites W2052415426 @default.
• W1987225239 cites W2056389198 @default.
• W1987225239 cites W2059117412 @default.
• W1987225239 cites W2066781880 @default.
• W1987225239 cites W2078166071 @default.
• W1987225239 cites W2080640632 @default.
• W1987225239 cites W2086181854 @default.
• W1987225239 cites W2090738767 @default.
• W1987225239 cites W2094813482 @default.
• W1987225239 cites W2100766258 @default.
• W1987225239 cites W2102170165 @default.
• W1987225239 cites W2106828113 @default.
• W1987225239 cites W2109208582 @default.
• W1987225239 cites W2123408996 @default.
• W1987225239 cites W2126128061 @default.
• W1987225239 cites W2130907973 @default.
• W1987225239 cites W2133623572 @default.
• W1987225239 cites W2145948868 @default.
• W1987225239 cites W2151479669 @default.
• W1987225239 cites W2162552344 @default.
• W1987225239 cites W2162997245 @default.
• W1987225239 cites W2165179388 @default.
• W1987225239 cites W2166759337 @default.
• W1987225239 cites W2168190460 @default.
• W1987225239 cites W2168319429 @default.
• W1987225239 cites W2169578249 @default.
• W1987225239 cites W2169980562 @default.
• W1987225239 cites W2170532212 @default.
• W1987225239 doi "https://doi.org/10.1016/j.neuron.2014.09.024" @default.
• W1987225239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4254581" @default.
• W1987225239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25451194" @default.
• W1987225239 hasPublicationYear "2014" @default.
• W1987225239 type Work @default.
• W1987225239 sameAs 1987225239 @default.
• W1987225239 citedByCount "121" @default.
• W1987225239 countsByYear W19872252392015 @default.
• W1987225239 countsByYear W19872252392016 @default.
• W1987225239 countsByYear W19872252392017 @default.
• W1987225239 countsByYear W19872252392018 @default.
• W1987225239 countsByYear W19872252392019 @default.
• W1987225239 countsByYear W19872252392020 @default.
• W1987225239 countsByYear W19872252392021 @default.
• W1987225239 countsByYear W19872252392022 @default.
• W1987225239 countsByYear W19872252392023 @default.
• W1987225239 crossrefType "journal-article" @default.
• W1987225239 hasAuthorship W1987225239A5059601597 @default.
• W1987225239 hasAuthorship W1987225239A5065713713 @default.
• W1987225239 hasAuthorship W1987225239A5081849997 @default.
• W1987225239 hasBestOaLocation W19872252391 @default.
• W1987225239 hasConcept C117718741 @default.
• W1987225239 hasConcept C11960822 @default.
• W1987225239 hasConcept C160268369 @default.
• W1987225239 hasConcept C169760540 @default.
• W1987225239 hasConcept C170493617 @default.
• W1987225239 hasConcept C185592680 @default.
• W1987225239 hasConcept C194973443 @default.
• W1987225239 hasConcept C25274449 @default.
• W1987225239 hasConcept C55493867 @default.
• W1987225239 hasConcept C5687787 @default.
• W1987225239 hasConcept C61174792 @default.
• W1987225239 hasConcept C63645605 @default.
• W1987225239 hasConcept C73009533 @default.
• W1987225239 hasConcept C86803240 @default.
• W1987225239 hasConcept C95444343 @default.
• W1987225239 hasConcept C98229152 @default.
• W1987225239 hasConceptScore W1987225239C117718741 @default.
• W1987225239 hasConceptScore W1987225239C11960822 @default.
• W1987225239 hasConceptScore W1987225239C160268369 @default.

• next