FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987236281> ?p ?o ?g. }

• W1987236281 endingPage "182" @default.
• W1987236281 startingPage "168" @default.
• W1987236281 abstract "In epithelial cells, the apical junctional complex (AJC), composed of tight junctions (TJs) and adherens junctions (AJs), maintains cell-surface polarity by forming a fence that prevents lateral movement and diffusion of proteins and lipids between the apical and basolateral PM and holds the epithelial monolayer intact through cell-cell contacts. Disassembly of this complex is a prime event in development and cell transformation. Maintenance of the AJC has been shown to involve mainly the actin cytoskeleton. Recent findings also point to the involvement of the microtubule (MT) system. Here we show the first evidence that in polarized epithelial MDCK cells, ARF-like protein 2 (ARL2) and beta-tubulin cofactor D, known to be involved in MT dynamics, have a role in disassembly of the AJC followed by cell dissociation from the epithelial monolayer, which is not dependent on MT depolymerization. In addition, we show that beta-tubulin cofactor D is partially localized to the lateral PM through its 15 C-terminal amino acids and intact MTs. ARL2 inhibited beta-tubulin cofactor D-dependent cell dissociation from the monolayer and AJC disassembly. To our knowledge, this is the first evidence that beta-tubulin cofactor D plays a role in cells independent of its presumed role in folding tubulin heterodimers. We conclude that ARL2 and beta-tubulin cofactor D participate in AJC disassembly and epithelial depolarization." @default.
• W1987236281 created "2016-06-24" @default.
• W1987236281 creator A5000428891 @default.
• W1987236281 creator A5010404572 @default.
• W1987236281 creator A5033233194 @default.
• W1987236281 creator A5041344853 @default.
• W1987236281 date "2007-08-17" @default.
• W1987236281 modified "2023-10-11" @default.
• W1987236281 title "β‐tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure" @default.
• W1987236281 cites W1585081876 @default.
• W1987236281 cites W1594528382 @default.
• W1987236281 cites W1861708461 @default.
• W1987236281 cites W1922542834 @default.
• W1987236281 cites W1984212919 @default.
• W1987236281 cites W1986694671 @default.
• W1987236281 cites W1991976042 @default.
• W1987236281 cites W1995139636 @default.
• W1987236281 cites W2004180261 @default.
• W1987236281 cites W2006812858 @default.
• W1987236281 cites W2012678565 @default.
• W1987236281 cites W2018143234 @default.
• W1987236281 cites W2045251540 @default.
• W1987236281 cites W2046560218 @default.
• W1987236281 cites W2048973430 @default.
• W1987236281 cites W2054526986 @default.
• W1987236281 cites W2057282956 @default.
• W1987236281 cites W2062601645 @default.
• W1987236281 cites W2071222888 @default.
• W1987236281 cites W2071233660 @default.
• W1987236281 cites W2075993250 @default.
• W1987236281 cites W2084626189 @default.
• W1987236281 cites W2089008488 @default.
• W1987236281 cites W2089307978 @default.
• W1987236281 cites W2100403812 @default.
• W1987236281 cites W2104213845 @default.
• W1987236281 cites W2110267612 @default.
• W1987236281 cites W2116104499 @default.
• W1987236281 cites W2126378968 @default.
• W1987236281 cites W2126464129 @default.
• W1987236281 cites W2126904219 @default.
• W1987236281 cites W2128826029 @default.
• W1987236281 cites W2134657042 @default.
• W1987236281 cites W2136772996 @default.
• W1987236281 cites W2144714494 @default.
• W1987236281 cites W2160440152 @default.
• W1987236281 cites W2163751558 @default.
• W1987236281 cites W2167638195 @default.
• W1987236281 cites W2170027619 @default.
• W1987236281 cites W2171951189 @default.
• W1987236281 cites W2183308769 @default.
• W1987236281 cites W2217436665 @default.
• W1987236281 cites W2396965045 @default.
• W1987236281 cites W4213094588 @default.
• W1987236281 doi "https://doi.org/10.1096/fj.06-7786com" @default.
• W1987236281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17704193" @default.
• W1987236281 hasPublicationYear "2007" @default.
• W1987236281 type Work @default.
• W1987236281 sameAs 1987236281 @default.
• W1987236281 citedByCount "20" @default.
• W1987236281 countsByYear W19872362812012 @default.
• W1987236281 countsByYear W19872362812014 @default.
• W1987236281 countsByYear W19872362812016 @default.
• W1987236281 countsByYear W19872362812017 @default.
• W1987236281 countsByYear W19872362812018 @default.
• W1987236281 countsByYear W19872362812019 @default.
• W1987236281 countsByYear W19872362812020 @default.
• W1987236281 countsByYear W19872362812021 @default.
• W1987236281 countsByYear W19872362812022 @default.
• W1987236281 crossrefType "journal-article" @default.
• W1987236281 hasAuthorship W1987236281A5000428891 @default.
• W1987236281 hasAuthorship W1987236281A5010404572 @default.
• W1987236281 hasAuthorship W1987236281A5033233194 @default.
• W1987236281 hasAuthorship W1987236281A5041344853 @default.
• W1987236281 hasConcept C125705527 @default.
• W1987236281 hasConcept C142669718 @default.
• W1987236281 hasConcept C1491633281 @default.
• W1987236281 hasConcept C149402561 @default.
• W1987236281 hasConcept C181199279 @default.
• W1987236281 hasConcept C185592680 @default.
• W1987236281 hasConcept C197957613 @default.
• W1987236281 hasConcept C201508349 @default.
• W1987236281 hasConcept C20418707 @default.
• W1987236281 hasConcept C29350253 @default.
• W1987236281 hasConcept C39587587 @default.
• W1987236281 hasConcept C49353375 @default.
• W1987236281 hasConcept C55493867 @default.
• W1987236281 hasConcept C84425145 @default.
• W1987236281 hasConcept C86803240 @default.
• W1987236281 hasConcept C95444343 @default.
• W1987236281 hasConceptScore W1987236281C125705527 @default.
• W1987236281 hasConceptScore W1987236281C142669718 @default.
• W1987236281 hasConceptScore W1987236281C1491633281 @default.
• W1987236281 hasConceptScore W1987236281C149402561 @default.
• W1987236281 hasConceptScore W1987236281C181199279 @default.
• W1987236281 hasConceptScore W1987236281C185592680 @default.
• W1987236281 hasConceptScore W1987236281C197957613 @default.
• W1987236281 hasConceptScore W1987236281C201508349 @default.
• W1987236281 hasConceptScore W1987236281C20418707 @default.

• next