Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987244430> ?p ?o ?g. }
- W1987244430 endingPage "425" @default.
- W1987244430 startingPage "415" @default.
- W1987244430 abstract "After a major illness or injury, immune status in critically ill patients may fluctuate between a marked proinflammatory response and an immunosuppressed state. Postinflammatory immunosuppression can result in increased susceptibility to infection. Alterations of cytokine production, such as suppression of IFNgamma and elevation of the anti-inflammatory cytokine IL-10, are believed to contribute to postinflammatory immunosuppression. We examined antimicrobial immunity in mice that had previously been subjected to a sublethal cecal ligation and puncture (CLP) as a model of major injury. Mice were challenged with Pseudomonas aeruginosa (5 x 10(7) CFU i.v.) on day 5 after CLP or sham surgery. Bacterial clearance in mice after CLP was impaired and associated with decreased production of IFNgamma and increased production of IL-10 in the early response to the Pseudomonas challenge. Pseudomonas-induced production of the IFNgamma-inducing factor IL-12 was also decreased in post-CLP mice. However, splenocytes from post-CLP mice remained responsive to exogenous stimulation with the IFNgamma-inducing cytokines IL-12, IL-15, and IL-18 as well as T-cell receptor activation. Furthermore, production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 were as high, or higher, in the post-CLP group compared with sham mice after P. aeruginosa challenge. Blockade of IL-10 did not reverse IL-12 and IFNgamma suppression in splenocytes from post-CLP mice. These studies show that suppressed bacterial clearance in post-CLP mice is associated with decreased production of IFNgamma and IL-12 and with increased production of IL-10 and proinflammatory cytokines." @default.
- W1987244430 created "2016-06-24" @default.
- W1987244430 creator A5014429489 @default.
- W1987244430 creator A5018585079 @default.
- W1987244430 creator A5028649129 @default.
- W1987244430 creator A5053697053 @default.
- W1987244430 creator A5071536683 @default.
- W1987244430 creator A5078143614 @default.
- W1987244430 date "2004-05-01" @default.
- W1987244430 modified "2023-10-12" @default.
- W1987244430 title "DIMINISHED BACTERIAL CLEARANCE IS ASSOCIATED WITH DECREASED IL-12 AND INTERFERON-?? PRODUCTION BUT A SUSTAINED PROINFLAMMATORY RESPONSE IN A MURINE MODEL OF POSTSEPTIC IMMUNOSUPPRESSION" @default.
- W1987244430 cites W1598162705 @default.
- W1987244430 cites W1599263328 @default.
- W1987244430 cites W1605146278 @default.
- W1987244430 cites W1939586679 @default.
- W1987244430 cites W1948034969 @default.
- W1987244430 cites W1963558945 @default.
- W1987244430 cites W1972757665 @default.
- W1987244430 cites W1987532719 @default.
- W1987244430 cites W1995228412 @default.
- W1987244430 cites W1997575279 @default.
- W1987244430 cites W2004617421 @default.
- W1987244430 cites W2008953730 @default.
- W1987244430 cites W2017828665 @default.
- W1987244430 cites W2018086295 @default.
- W1987244430 cites W2031039655 @default.
- W1987244430 cites W2031650654 @default.
- W1987244430 cites W2035966701 @default.
- W1987244430 cites W2040617020 @default.
- W1987244430 cites W2049927822 @default.
- W1987244430 cites W2056796152 @default.
- W1987244430 cites W2061505985 @default.
- W1987244430 cites W2062056147 @default.
- W1987244430 cites W2063641727 @default.
- W1987244430 cites W2074372315 @default.
- W1987244430 cites W2074618631 @default.
- W1987244430 cites W2082699049 @default.
- W1987244430 cites W2089296531 @default.
- W1987244430 cites W2089930580 @default.
- W1987244430 cites W2106173333 @default.
- W1987244430 cites W2114914602 @default.
- W1987244430 cites W2121328878 @default.
- W1987244430 cites W2129909496 @default.
- W1987244430 cites W2134768631 @default.
- W1987244430 cites W2144824088 @default.
- W1987244430 cites W4292339330 @default.
- W1987244430 cites W95187520 @default.
- W1987244430 doi "https://doi.org/10.1097/00024382-200405000-00004" @default.
- W1987244430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15087817" @default.
- W1987244430 hasPublicationYear "2004" @default.
- W1987244430 type Work @default.
- W1987244430 sameAs 1987244430 @default.
- W1987244430 citedByCount "69" @default.
- W1987244430 countsByYear W19872444302012 @default.
- W1987244430 countsByYear W19872444302013 @default.
- W1987244430 countsByYear W19872444302014 @default.
- W1987244430 countsByYear W19872444302015 @default.
- W1987244430 countsByYear W19872444302016 @default.
- W1987244430 countsByYear W19872444302017 @default.
- W1987244430 countsByYear W19872444302018 @default.
- W1987244430 countsByYear W19872444302020 @default.
- W1987244430 countsByYear W19872444302021 @default.
- W1987244430 countsByYear W19872444302022 @default.
- W1987244430 crossrefType "journal-article" @default.
- W1987244430 hasAuthorship W1987244430A5014429489 @default.
- W1987244430 hasAuthorship W1987244430A5018585079 @default.
- W1987244430 hasAuthorship W1987244430A5028649129 @default.
- W1987244430 hasAuthorship W1987244430A5053697053 @default.
- W1987244430 hasAuthorship W1987244430A5071536683 @default.
- W1987244430 hasAuthorship W1987244430A5078143614 @default.
- W1987244430 hasBestOaLocation W19872444301 @default.
- W1987244430 hasConcept C164027704 @default.
- W1987244430 hasConcept C187316574 @default.
- W1987244430 hasConcept C189976730 @default.
- W1987244430 hasConcept C203014093 @default.
- W1987244430 hasConcept C2776914184 @default.
- W1987244430 hasConcept C2778690821 @default.
- W1987244430 hasConcept C2780252810 @default.
- W1987244430 hasConcept C71924100 @default.
- W1987244430 hasConcept C8891405 @default.
- W1987244430 hasConceptScore W1987244430C164027704 @default.
- W1987244430 hasConceptScore W1987244430C187316574 @default.
- W1987244430 hasConceptScore W1987244430C189976730 @default.
- W1987244430 hasConceptScore W1987244430C203014093 @default.
- W1987244430 hasConceptScore W1987244430C2776914184 @default.
- W1987244430 hasConceptScore W1987244430C2778690821 @default.
- W1987244430 hasConceptScore W1987244430C2780252810 @default.
- W1987244430 hasConceptScore W1987244430C71924100 @default.
- W1987244430 hasConceptScore W1987244430C8891405 @default.
- W1987244430 hasIssue "5" @default.
- W1987244430 hasLocation W19872444301 @default.
- W1987244430 hasLocation W19872444302 @default.
- W1987244430 hasOpenAccess W1987244430 @default.
- W1987244430 hasPrimaryLocation W19872444301 @default.
- W1987244430 hasRelatedWork W181678093 @default.
- W1987244430 hasRelatedWork W2005666125 @default.
- W1987244430 hasRelatedWork W2047209980 @default.
- W1987244430 hasRelatedWork W2127503919 @default.