Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987247105> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1987247105 endingPage "359" @default.
- W1987247105 startingPage "357" @default.
- W1987247105 abstract "Glucagonlike peptide-2 (GLP-2), a product of the posttranslational processing of proglucagon, has been shown to enhance mucosal mass and function in both normal intestine and in the residual intestine after massive small bowel resection. This study was designed to determine if a synthetic, protease-resistant analogue of GLP-2 (GLP-2alpha) can enhance mucosal mass in small intestine after ischemia and reperfusion (I/R) injury.Ten young adult male Sprague-Dawley rats underwent laparotomy and superior mesenteric artery occlusion for a period of 40 minutes. During this period of ischemia, each rat underwent placement of a jugular venous catheter that was connected to a subcutaneously placed osmotic pump designed to deliver its contents over 3 days. The rats were divided into 2 groups based on the contents of the pumps: group 1, saline at 1 microL/h (n = 6) and group 2, GLP-2alpha at 100 microg/kg/d (n = 4). Three days after insertion of the pumps the small intestine was harvested from the surviving rats for determination of mucosal DNA and protein content. Statistical analysis was performed using unpaired Student's t test.After I/R injury to the small intestine, a 3-day systemic infusion of GLP-2alpha significantly increased mucosal DNA content 41% (P<.05) and mucosal protein content 60% (P<.05) when compared with saline-treated controls. In addition, infusion of GLP-2alpha reduced mortality from 50% to 25%.These data show for the first time that GLP-2alpha enhances mucosal mass following I/R injury to the small intestine. GLP-2alpha may be of benefit to patients with intestinal ischemia syndromes such as necrotizing enterocolitis and midgut volvulus." @default.
- W1987247105 created "2016-06-24" @default.
- W1987247105 creator A5030486542 @default.
- W1987247105 creator A5040902522 @default.
- W1987247105 creator A5064121372 @default.
- W1987247105 date "2000-02-01" @default.
- W1987247105 modified "2023-10-15" @default.
- W1987247105 title "Glucagonlike peptide-2 analogue enhances intestinal mucosal mass after ischemia and reperfusion" @default.
- W1987247105 cites W1775749144 @default.
- W1987247105 cites W1906197854 @default.
- W1987247105 cites W1975731500 @default.
- W1987247105 cites W1993086944 @default.
- W1987247105 cites W2010373786 @default.
- W1987247105 cites W2013395086 @default.
- W1987247105 cites W2075710487 @default.
- W1987247105 cites W2120133907 @default.
- W1987247105 cites W2133396569 @default.
- W1987247105 cites W2171366713 @default.
- W1987247105 doi "https://doi.org/10.1016/s0022-3468(00)90040-x" @default.
- W1987247105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10693696" @default.
- W1987247105 hasPublicationYear "2000" @default.
- W1987247105 type Work @default.
- W1987247105 sameAs 1987247105 @default.
- W1987247105 citedByCount "53" @default.
- W1987247105 countsByYear W19872471052012 @default.
- W1987247105 countsByYear W19872471052013 @default.
- W1987247105 countsByYear W19872471052014 @default.
- W1987247105 countsByYear W19872471052015 @default.
- W1987247105 countsByYear W19872471052016 @default.
- W1987247105 countsByYear W19872471052017 @default.
- W1987247105 countsByYear W19872471052018 @default.
- W1987247105 crossrefType "journal-article" @default.
- W1987247105 hasAuthorship W1987247105A5030486542 @default.
- W1987247105 hasAuthorship W1987247105A5040902522 @default.
- W1987247105 hasAuthorship W1987247105A5064121372 @default.
- W1987247105 hasConcept C126322002 @default.
- W1987247105 hasConcept C134018914 @default.
- W1987247105 hasConcept C141071460 @default.
- W1987247105 hasConcept C2776398474 @default.
- W1987247105 hasConcept C2777180221 @default.
- W1987247105 hasConcept C2777397205 @default.
- W1987247105 hasConcept C2777882243 @default.
- W1987247105 hasConcept C2779281246 @default.
- W1987247105 hasConcept C2779820108 @default.
- W1987247105 hasConcept C2780114680 @default.
- W1987247105 hasConcept C2780768396 @default.
- W1987247105 hasConcept C2780778865 @default.
- W1987247105 hasConcept C2781046184 @default.
- W1987247105 hasConcept C2781219945 @default.
- W1987247105 hasConcept C541997718 @default.
- W1987247105 hasConcept C55493867 @default.
- W1987247105 hasConcept C555293320 @default.
- W1987247105 hasConcept C71924100 @default.
- W1987247105 hasConcept C78722104 @default.
- W1987247105 hasConcept C86803240 @default.
- W1987247105 hasConcept C90924648 @default.
- W1987247105 hasConceptScore W1987247105C126322002 @default.
- W1987247105 hasConceptScore W1987247105C134018914 @default.
- W1987247105 hasConceptScore W1987247105C141071460 @default.
- W1987247105 hasConceptScore W1987247105C2776398474 @default.
- W1987247105 hasConceptScore W1987247105C2777180221 @default.
- W1987247105 hasConceptScore W1987247105C2777397205 @default.
- W1987247105 hasConceptScore W1987247105C2777882243 @default.
- W1987247105 hasConceptScore W1987247105C2779281246 @default.
- W1987247105 hasConceptScore W1987247105C2779820108 @default.
- W1987247105 hasConceptScore W1987247105C2780114680 @default.
- W1987247105 hasConceptScore W1987247105C2780768396 @default.
- W1987247105 hasConceptScore W1987247105C2780778865 @default.
- W1987247105 hasConceptScore W1987247105C2781046184 @default.
- W1987247105 hasConceptScore W1987247105C2781219945 @default.
- W1987247105 hasConceptScore W1987247105C541997718 @default.
- W1987247105 hasConceptScore W1987247105C55493867 @default.
- W1987247105 hasConceptScore W1987247105C555293320 @default.
- W1987247105 hasConceptScore W1987247105C71924100 @default.
- W1987247105 hasConceptScore W1987247105C78722104 @default.
- W1987247105 hasConceptScore W1987247105C86803240 @default.
- W1987247105 hasConceptScore W1987247105C90924648 @default.
- W1987247105 hasIssue "2" @default.
- W1987247105 hasLocation W19872471051 @default.
- W1987247105 hasLocation W19872471052 @default.
- W1987247105 hasOpenAccess W1987247105 @default.
- W1987247105 hasPrimaryLocation W19872471051 @default.
- W1987247105 hasRelatedWork W1922253981 @default.
- W1987247105 hasRelatedWork W1999687468 @default.
- W1987247105 hasRelatedWork W2076844999 @default.
- W1987247105 hasRelatedWork W2092926285 @default.
- W1987247105 hasRelatedWork W2129615252 @default.
- W1987247105 hasRelatedWork W2164863137 @default.
- W1987247105 hasRelatedWork W2383585458 @default.
- W1987247105 hasRelatedWork W3098180984 @default.
- W1987247105 hasRelatedWork W3174110372 @default.
- W1987247105 hasRelatedWork W55001064 @default.
- W1987247105 hasVolume "35" @default.
- W1987247105 isParatext "false" @default.
- W1987247105 isRetracted "false" @default.
- W1987247105 magId "1987247105" @default.
- W1987247105 workType "article" @default.