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• W1987247242 startingPage "954" @default.
• W1987247242 abstract "Abstract Background Active smoking is known to increase asthma symptoms and bronchial hyper‐responsiveness (BHR) while decreasing pulmonary function in adults, but few studies have addressed these issues in adolescents. Methods We conducted a cross‐sectional survey involving questionnaires and assessment of urinary cotinine levels among 1,492 adolescents from three urban areas of South Korea. Current smoking was defined as having smoked more than 1 day in the prior 30 days or having urine cotinine levels ≥100 ng/ml. Spirometry, skin tests, and methacholine challenge tests were performed on adolescents in Seoul (n = 724). Results The prevalence of current smoking was 8.2% in boys and 2.4% in girls. Reports of wheeze and exercise‐induced wheeze in the previous 12 months were more frequent in smokers than nonsmokers (15.2% vs. 8.5%, P = 0.024, and 20.4% vs. 10.7%, P = 0.004, respectively). In multiple logistic regression analysis, current smoking was found to be a significant risk factor for having wheezed in previous 12 months (OR = 4.5, 95% CI 1.5–13.2) and having exercise‐induced wheezing in previous 12 months (OR = 8.7, 95% CI, 3.7–20.9). The subgroup analysis revealed that the FEV 1 /FVC was lower in smokers than nonsmokers (mean ± SD, 105.1 ± 8.6% vs. 107.8 ± 7.8%, P = 0.019). In contrast, there was no significant difference in BHR. The effect of smoking on asthma symptoms were more pronounced in non‐atopic compared with atopic adolescents. Conclusion Current smoking was significantly associated with symptoms of asthma, such as having recent wheezing and recent exercise‐induced wheezing, especially for non‐atopics, in Korean adolescent population. Current smoking was further associated with lower pulmonary function, but not BHR. Pediatr Pulmonol. 2009; 44:954–961. ©2009 Wiley‐Liss, Inc." @default.
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• W1987247242 date "2009-09-02" @default.
• W1987247242 modified "2023-10-15" @default.
• W1987247242 title "Effect of active smoking on asthma symptoms, pulmonary function, and BHR in adolescents" @default.
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• W1987247242 doi "https://doi.org/10.1002/ppul.21066" @default.
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