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- W1987251505 abstract "A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure–activity relationship studies are presented." @default.
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- W1987251505 date "2011-04-01" @default.
- W1987251505 modified "2023-10-18" @default.
- W1987251505 title "Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors" @default.
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- W1987251505 doi "https://doi.org/10.1016/j.bmcl.2011.02.037" @default.
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