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- W1987252817 abstract "In this study, we attempted to identify the mechanisms of paeoniflorin on antinociceptive effects in mice. Paeoniflorin (48, 96, 240, 480 μg, i.c.v.) showed dose-related antinociception both on the early and late phases of formalin test in mice. Moreover, paeoniflorin (48 μg, i.c.v.) could potentiate the antinociception of morphrine (0.5, 1.0 mg/kg, s.c.) in the formalin test. However, the antinociceptive effects of paeoniflorin were not potentiated by l-arginine (600 mg/kg, i.p.) or antagonized by β-funaltrexamine (β-FNA) (10 μg, i.c.v.), ICI-174,864 (1 μg, i.c.v.) and ryanodine (10 ng, i.c.v.) on both the early and late phases of formalin test. l-NAME (75 mg/kg, i.p.) could reverse the effect of paeoniflorin on the late phase of formalin test. Naloxone (1 mg/kg, i.p.) and nor-binaltorphimine (nor-BNI) (1 μg, i.c.v.) could block the paeoniflorin-induced antinociception on the early phase of formalin test. These results suggested that the central antinociceptive effects of paeoniflorin on formalin test in mice were mediated by the activation of κ-opioid receptor and not related to the increase of intracellular calcium." @default.
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- W1987252817 date "2001-05-01" @default.
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- W1987252817 title "Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice" @default.
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- W1987252817 doi "https://doi.org/10.1016/s0378-8741(00)00403-7" @default.
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