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- W1987254209 abstract "Blood coagulation and inflammation play a key role in atherosclerosis and thrombosis. Candidate gene and genome wide association studies have identified potential specific genes that might have a causal role in these pathogenic processes. The analysis of quantitative traits is more powerful as they are closer to direct gene action than disease phenotypes. Thus linkage-based studies on extended families might be useful both to estimate the heritability and to map the genetic loci responsible for the regulation of the trait.Family-based studies may estimate high heritability for thrombosis and quantitative traits regarding both platelet aggregation and blood coagulation. Some specific loci relevant to thrombosis have been identified, with some of them showing a direct pleiotropic effect on the risk of thrombosis.Haemostasis factors can be activated by inflammatory stimuli. Fibrinogen level is genetically correlated with C-reactive protein levels with a link for both traits on chromosomes 12 and 21. Genes related to prostanoid biosynthesis, involved both in inflammation and thrombosis, show high heritability levels in both enzyme expression and prostanoid production.Considering that few large family-based linkage studies have as yet been performed on haemostasis and inflammation-related traits, additional studies are highly needed. We are performing a family-based linkage study on large pedigrees (750 subjects from 23 families with juvenile myocardial infarction and 31 control families), to identify genes responsible for quantitative traits involved in the pathway progressively going from inflammation to haemostasis, cell activation, thrombus formation and cardiovascular events." @default.
- W1987254209 created "2016-06-24" @default.
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- W1987254209 creator A5050757013 @default.
- W1987254209 creator A5069797729 @default.
- W1987254209 date "1998-09-01" @default.
- W1987254209 modified "2023-09-26" @default.
- W1987254209 title "Contribution of factor VII, fibrinogen and fibrinolytic components to the risk of ischaemic cardiovascular disease: their genetic determinants" @default.
- W1987254209 cites W1008280890 @default.
- W1987254209 cites W1505365469 @default.
- W1987254209 cites W1552492783 @default.
- W1987254209 cites W1560643627 @default.
- W1987254209 cites W1574588787 @default.
- W1987254209 cites W1612519001 @default.
- W1987254209 cites W1630061106 @default.
- W1987254209 cites W1651383390 @default.
- W1987254209 cites W183014409 @default.
- W1987254209 cites W1965728207 @default.
- W1987254209 cites W1969230739 @default.
- W1987254209 cites W1969632860 @default.
- W1987254209 cites W1972446012 @default.
- W1987254209 cites W1972729110 @default.
- W1987254209 cites W1972732333 @default.
- W1987254209 cites W1973674178 @default.
- W1987254209 cites W1975015154 @default.
- W1987254209 cites W1978869452 @default.
- W1987254209 cites W1981655129 @default.
- W1987254209 cites W1984353716 @default.
- W1987254209 cites W1984954977 @default.
- W1987254209 cites W1998036319 @default.
- W1987254209 cites W1998083394 @default.
- W1987254209 cites W1999010321 @default.
- W1987254209 cites W2001003226 @default.
- W1987254209 cites W2005521257 @default.
- W1987254209 cites W2005718118 @default.
- W1987254209 cites W2006678791 @default.
- W1987254209 cites W2010545674 @default.
- W1987254209 cites W2010891844 @default.
- W1987254209 cites W2014178747 @default.
- W1987254209 cites W2015257465 @default.
- W1987254209 cites W2015338993 @default.
- W1987254209 cites W20164601 @default.
- W1987254209 cites W2022262808 @default.
- W1987254209 cites W2024991598 @default.
- W1987254209 cites W2025332375 @default.
- W1987254209 cites W2025767551 @default.
- W1987254209 cites W2026878362 @default.
- W1987254209 cites W2027383668 @default.
- W1987254209 cites W2030241428 @default.
- W1987254209 cites W2030596611 @default.
- W1987254209 cites W2031018845 @default.
- W1987254209 cites W2033307460 @default.
- W1987254209 cites W2034888656 @default.
- W1987254209 cites W2036363775 @default.
- W1987254209 cites W2039342466 @default.
- W1987254209 cites W2039831544 @default.
- W1987254209 cites W2042103448 @default.
- W1987254209 cites W2042962121 @default.
- W1987254209 cites W2043951336 @default.
- W1987254209 cites W2044372501 @default.
- W1987254209 cites W2047122524 @default.
- W1987254209 cites W2049950622 @default.
- W1987254209 cites W2051303471 @default.
- W1987254209 cites W2053868688 @default.
- W1987254209 cites W2055102864 @default.
- W1987254209 cites W2059287236 @default.
- W1987254209 cites W2060422362 @default.
- W1987254209 cites W2063144465 @default.
- W1987254209 cites W2064736463 @default.
- W1987254209 cites W2065023641 @default.
- W1987254209 cites W2076500453 @default.
- W1987254209 cites W2081134652 @default.
- W1987254209 cites W2081377369 @default.
- W1987254209 cites W2084124265 @default.
- W1987254209 cites W2084417976 @default.
- W1987254209 cites W2086303216 @default.
- W1987254209 cites W2088959855 @default.
- W1987254209 cites W2089031194 @default.
- W1987254209 cites W2091950451 @default.
- W1987254209 cites W2092362047 @default.
- W1987254209 cites W2093045218 @default.
- W1987254209 cites W2094630627 @default.
- W1987254209 cites W2095045276 @default.
- W1987254209 cites W2097843661 @default.
- W1987254209 cites W2100404719 @default.
- W1987254209 cites W2101967721 @default.
- W1987254209 cites W2104734287 @default.
- W1987254209 cites W2109983542 @default.
- W1987254209 cites W2110474655 @default.
- W1987254209 cites W2112357129 @default.
- W1987254209 cites W2116284648 @default.
- W1987254209 cites W2119482854 @default.
- W1987254209 cites W2120549911 @default.
- W1987254209 cites W2124671503 @default.
- W1987254209 cites W2125047098 @default.