FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987260208> ?p ?o ?g. }

• W1987260208 endingPage "326" @default.
• W1987260208 startingPage "319" @default.
• W1987260208 abstract "Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein 2 (MeCP2) gene. In previous studies, monoaminergic dysfunctions have been detected in patients with RTT and in a murine model of RTT, the Mecp2-null mouse. Therefore, the pathogenesis of RTT is thought to involve impairments in the monoaminergic systems. However, there have been limited data showing that the impairment of monoamines leads to early symptoms during development. We used histochemistry to study the somatosensory barrel cortex in the B6.129P2(C)-Mecp2tm1.1Bird mouse model of RTT. The barrel cortex is widely used to investigate neuronal development and its regulation by various neurotransmitters including 5-HT. 5-HT levels were measured by high performance liquid chromatography with electrochemical detection (HPLC/EC), and serotonin transporter (SERT) and 5-HT1B receptor mRNAs were measured in the somatosensory cortex, thalamus and striatum on postnatal days (P) 10, P20 and P40. Mecp2-null mice (Mecp2−/y) had significantly smaller barrel fields than age-matched wild-type controls (Mecp2+/y) on P10 and P40, but the topographic map was accurately formed. Levels of 5-HT, and SERT and 5-HT1B receptor mRNA expression in the somatosensory cortex did not differ significantly between the Mecp2-null and wild-type mice on P10. However, thalamic 5-HT was reduced in Mecp2-null mice. Our data indicate that a lack of MeCP2 may disturb the refinement of the barrel cortex in the early postnatal period. Our findings suggest that a decrease in thalamic 5-HT might be involved in this phenomenon." @default.
• W1987260208 created "2016-06-24" @default.
• W1987260208 creator A5006934543 @default.
• W1987260208 creator A5007996627 @default.
• W1987260208 creator A5010379214 @default.
• W1987260208 creator A5029289781 @default.
• W1987260208 creator A5030343695 @default.
• W1987260208 creator A5040573427 @default.
• W1987260208 creator A5040876787 @default.
• W1987260208 creator A5045806272 @default.
• W1987260208 creator A5061020283 @default.
• W1987260208 creator A5071385074 @default.
• W1987260208 creator A5077631265 @default.
• W1987260208 creator A5080156911 @default.
• W1987260208 date "2013-11-01" @default.
• W1987260208 modified "2023-10-16" @default.
• W1987260208 title "Altered somatosensory barrel cortex refinement in the developing brain of Mecp2-null mice" @default.
• W1987260208 cites W1488115555 @default.
• W1987260208 cites W1520468704 @default.
• W1987260208 cites W1530652082 @default.
• W1987260208 cites W1559742681 @default.
• W1987260208 cites W1561541164 @default.
• W1987260208 cites W1713895945 @default.
• W1987260208 cites W1776942521 @default.
• W1987260208 cites W1931238753 @default.
• W1987260208 cites W1956111175 @default.
• W1987260208 cites W1971512830 @default.
• W1987260208 cites W1979223448 @default.
• W1987260208 cites W1984803891 @default.
• W1987260208 cites W1991923036 @default.
• W1987260208 cites W1995167976 @default.
• W1987260208 cites W1996779312 @default.
• W1987260208 cites W2000647834 @default.
• W1987260208 cites W2008721272 @default.
• W1987260208 cites W2047390168 @default.
• W1987260208 cites W2055119063 @default.
• W1987260208 cites W2056725005 @default.
• W1987260208 cites W2062976968 @default.
• W1987260208 cites W2063840478 @default.
• W1987260208 cites W2068358888 @default.
• W1987260208 cites W2082787641 @default.
• W1987260208 cites W2085936836 @default.
• W1987260208 cites W2088996542 @default.
• W1987260208 cites W2099966429 @default.
• W1987260208 cites W2107855944 @default.
• W1987260208 cites W2108657146 @default.
• W1987260208 cites W2118607105 @default.
• W1987260208 cites W2127311839 @default.
• W1987260208 cites W2152668149 @default.
• W1987260208 cites W2153065561 @default.
• W1987260208 cites W2165971121 @default.
• W1987260208 cites W2171939481 @default.
• W1987260208 cites W2397166584 @default.
• W1987260208 cites W4250317562 @default.
• W1987260208 doi "https://doi.org/10.1016/j.brainres.2013.09.017" @default.
• W1987260208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24060648" @default.
• W1987260208 hasPublicationYear "2013" @default.
• W1987260208 type Work @default.
• W1987260208 sameAs 1987260208 @default.
• W1987260208 citedByCount "7" @default.
• W1987260208 countsByYear W19872602082015 @default.
• W1987260208 countsByYear W19872602082017 @default.
• W1987260208 countsByYear W19872602082019 @default.
• W1987260208 countsByYear W19872602082021 @default.
• W1987260208 countsByYear W19872602082023 @default.
• W1987260208 crossrefType "journal-article" @default.
• W1987260208 hasAuthorship W1987260208A5006934543 @default.
• W1987260208 hasAuthorship W1987260208A5007996627 @default.
• W1987260208 hasAuthorship W1987260208A5010379214 @default.
• W1987260208 hasAuthorship W1987260208A5029289781 @default.
• W1987260208 hasAuthorship W1987260208A5030343695 @default.
• W1987260208 hasAuthorship W1987260208A5040573427 @default.
• W1987260208 hasAuthorship W1987260208A5040876787 @default.
• W1987260208 hasAuthorship W1987260208A5045806272 @default.
• W1987260208 hasAuthorship W1987260208A5061020283 @default.
• W1987260208 hasAuthorship W1987260208A5071385074 @default.
• W1987260208 hasAuthorship W1987260208A5077631265 @default.
• W1987260208 hasAuthorship W1987260208A5080156911 @default.
• W1987260208 hasConcept C104317684 @default.
• W1987260208 hasConcept C126322002 @default.
• W1987260208 hasConcept C127716648 @default.
• W1987260208 hasConcept C134018914 @default.
• W1987260208 hasConcept C169760540 @default.
• W1987260208 hasConcept C170493617 @default.
• W1987260208 hasConcept C172497186 @default.
• W1987260208 hasConcept C187714386 @default.
• W1987260208 hasConcept C2775864247 @default.
• W1987260208 hasConcept C2777348757 @default.
• W1987260208 hasConcept C2777543196 @default.
• W1987260208 hasConcept C2778863441 @default.
• W1987260208 hasConcept C2779246727 @default.
• W1987260208 hasConcept C2781347215 @default.
• W1987260208 hasConcept C42251903 @default.
• W1987260208 hasConcept C54355233 @default.
• W1987260208 hasConcept C71924100 @default.
• W1987260208 hasConcept C86803240 @default.
• W1987260208 hasConceptScore W1987260208C104317684 @default.
• W1987260208 hasConceptScore W1987260208C126322002 @default.

• next