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- W1987266087 abstract "Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of active RhoGTP and a decrease in phosphorylated myosin light chain (MLC). Finally, we demonstrated a novel interaction between TPC1 and citron kinase (CIT). These results identify TPC1 as a central component of cytokinetic control, specifically during abscission, and introduce a means by which the endolysosomal system may play an active role in this process." @default.
- W1987266087 created "2016-06-24" @default.
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- W1987266087 date "2015-01-02" @default.
- W1987266087 modified "2023-10-01" @default.
- W1987266087 title "Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis" @default.
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- W1987266087 doi "https://doi.org/10.4161/19336950.2014.978676" @default.
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