Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987287339> ?p ?o ?g. }
- W1987287339 endingPage "826" @default.
- W1987287339 startingPage "819" @default.
- W1987287339 abstract "The expression of several cell surface proteins including the transferrin receptor and 4F2 antigen is induced when quiescent cells are activated and proliferate. We have studied this induction in mouse spleen cells after stimulation with 4 beta-phorbol 12-myristate 13-acetate (PMA), the Ca(2+)-ionophore, ionomycin and recombinant interleukin-2 (IL-2). The 4F2 antigen heavy chain and transferrin receptor mRNA were barely detectable in resting cells, but increased 60-fold within 4 h of growth stimulation. The corresponding proteins became measurable at the cell surface after 6 h, prior to the S phase. In run-on transcription assays the transferrin receptor gene was transcribed to almost the same extent in resting and growth-stimulated cell populations and the 4F2 antigen heavy chain gene was induced fivefold. This suggests that post-transcriptional control mechanisms are mainly responsible for the accumulation of the respective mRNA at the onset of cell proliferation. In the case of the transferrin receptor, the induction correlated with an activation of the mRNA-binding iron-regulatory factor which is known to increase the stability of the cytoplasmic transferrin receptor mRNA." @default.
- W1987287339 created "2016-06-24" @default.
- W1987287339 creator A5020891892 @default.
- W1987287339 creator A5054056943 @default.
- W1987287339 date "1991-12-01" @default.
- W1987287339 modified "2023-10-02" @default.
- W1987287339 title "Post-transcriptional regulation of the transferrin receptor and 4F2 antigen heavy chain mRNA during growth activation of spleen cells" @default.
- W1987287339 cites W138004826 @default.
- W1987287339 cites W1488035272 @default.
- W1987287339 cites W1491735784 @default.
- W1987287339 cites W1494311717 @default.
- W1987287339 cites W1505773153 @default.
- W1987287339 cites W1509578913 @default.
- W1987287339 cites W1513400082 @default.
- W1987287339 cites W1515388283 @default.
- W1987287339 cites W1520282358 @default.
- W1987287339 cites W1525275679 @default.
- W1987287339 cites W1542515219 @default.
- W1987287339 cites W1569593364 @default.
- W1987287339 cites W1574134736 @default.
- W1987287339 cites W1575813177 @default.
- W1987287339 cites W1594263740 @default.
- W1987287339 cites W1753735758 @default.
- W1987287339 cites W1778881698 @default.
- W1987287339 cites W1847068645 @default.
- W1987287339 cites W1848751398 @default.
- W1987287339 cites W1893796326 @default.
- W1987287339 cites W1910815336 @default.
- W1987287339 cites W191528488 @default.
- W1987287339 cites W1956097919 @default.
- W1987287339 cites W1971257471 @default.
- W1987287339 cites W1972101833 @default.
- W1987287339 cites W1973592220 @default.
- W1987287339 cites W1974391793 @default.
- W1987287339 cites W1975363517 @default.
- W1987287339 cites W1981906297 @default.
- W1987287339 cites W1982129404 @default.
- W1987287339 cites W1993210315 @default.
- W1987287339 cites W1996164869 @default.
- W1987287339 cites W1998070104 @default.
- W1987287339 cites W1999347013 @default.
- W1987287339 cites W2000595280 @default.
- W1987287339 cites W2002796914 @default.
- W1987287339 cites W2005854249 @default.
- W1987287339 cites W2007040484 @default.
- W1987287339 cites W2012565545 @default.
- W1987287339 cites W2014669590 @default.
- W1987287339 cites W2014704429 @default.
- W1987287339 cites W2015113703 @default.
- W1987287339 cites W2017282278 @default.
- W1987287339 cites W2023361302 @default.
- W1987287339 cites W2033760796 @default.
- W1987287339 cites W2034280067 @default.
- W1987287339 cites W2056744253 @default.
- W1987287339 cites W2064974294 @default.
- W1987287339 cites W2078119356 @default.
- W1987287339 cites W2085866164 @default.
- W1987287339 cites W2088135627 @default.
- W1987287339 cites W2094794452 @default.
- W1987287339 cites W2095302405 @default.
- W1987287339 cites W2108302526 @default.
- W1987287339 cites W2124983348 @default.
- W1987287339 cites W2129521775 @default.
- W1987287339 cites W2145059527 @default.
- W1987287339 cites W2148231718 @default.
- W1987287339 cites W2153407527 @default.
- W1987287339 cites W2160225986 @default.
- W1987287339 cites W236654392 @default.
- W1987287339 cites W4256544981 @default.
- W1987287339 cites W4294216491 @default.
- W1987287339 cites W59367387 @default.
- W1987287339 cites W61805095 @default.
- W1987287339 doi "https://doi.org/10.1111/j.1432-1033.1991.tb16438.x" @default.
- W1987287339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1722457" @default.
- W1987287339 hasPublicationYear "1991" @default.
- W1987287339 type Work @default.
- W1987287339 sameAs 1987287339 @default.
- W1987287339 citedByCount "38" @default.
- W1987287339 countsByYear W19872873392012 @default.
- W1987287339 countsByYear W19872873392013 @default.
- W1987287339 crossrefType "journal-article" @default.
- W1987287339 hasAuthorship W1987287339A5020891892 @default.
- W1987287339 hasAuthorship W1987287339A5054056943 @default.
- W1987287339 hasBestOaLocation W19872873391 @default.
- W1987287339 hasConcept C104317684 @default.
- W1987287339 hasConcept C105580179 @default.
- W1987287339 hasConcept C134018914 @default.
- W1987287339 hasConcept C147483822 @default.
- W1987287339 hasConcept C150194340 @default.
- W1987287339 hasConcept C153911025 @default.
- W1987287339 hasConcept C170493617 @default.
- W1987287339 hasConcept C185592680 @default.
- W1987287339 hasConcept C203014093 @default.
- W1987287339 hasConcept C22814914 @default.
- W1987287339 hasConcept C24998067 @default.
- W1987287339 hasConcept C2776989580 @default.
- W1987287339 hasConcept C32264632 @default.
- W1987287339 hasConcept C55493867 @default.