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- W1987290460 abstract "In awake human subjects, neural activity was recorded from intact skin nerve with percutaneously inserted tungsten microelectrodes. C fibre responses induced by natural and electrical skin stimuli were studied before and after long term topical application of an anesthetic composition. After the anesthetic had worked on the skin for 1 - 1.5 h, the responsiveness of cutaneous C receptors was suppressed. Concomitantly, the subjects reported a decrease in perception of previously painful stimuli agreeing with the widely accepted notion that there is a close correlation between afferent activity in C fibres and perception of pain. It is suggested that the procedures outlined can be used as an experimental model for objective studies of how topical anesthetics penetrate into the skin and block neural elements with nociceptive functions in alert man. ZUSAMMENFASSUNG Mit Wolframmikroelektroden wurde bei wachen Versuchspersonen perkutan die Aktivität unversehrter Hautnerven registriert. C-Faserpotentiale wurden durch mechanische und elektrische Hautreize evoziert und wurden vor und nach Langzeiteinwirkung eines Lokalanaestheticum (Ketocain®-Komplex) verglichen. Die Applikation dieses Anaestheticum auf die Haut ergab eine deutlich verminderte Excitabilität entsprechender C-Receptoren und parallel dazu eine verminderte Intensitat zuvor schmerzhaft empfundener Reize. Diese Befunde belegen die Tatsache, dass Schmerzreize durch C-Fasern übermittelt werden. Die hier beschriebene Methode kann als experimentelles Modell zur objektiven Erfassung der Wirkung von Lokalanaesthetica dienen. Sie liefert objektive Angaben über die Penetration durch die Haut und über die Blockierung nozizeptiver Receptoren am wachen Menschen." @default.
- W1987290460 created "2016-06-24" @default.
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- W1987290460 date "1974-12-01" @default.
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- W1987290460 title "Blocking Effects of A Topical Anesthetic Composition Containing Ketocaine on Cutaneous C Receptor Responses in Alert Man" @default.
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- W1987290460 doi "https://doi.org/10.1111/j.1399-6576.1974.tb01184.x" @default.
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