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- W1987291092 endingPage "453" @default.
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- W1987291092 abstract "The identification of cross-neutralizing antibodies to HIV-1 is important for designing antigens aimed at eliciting similar antibodies upon immunization. The monoclonal antibody (mAb) F425-B4e8 had been suggested previously to bind an epitope at the base of V3 and shown to neutralize two primary HIV isolates. Here, we have assessed the neutralization breadth of mAb F425-B4e8 using a 40-member panel of primary HIV-1 and determined the epitope specificity of the mAb. The antibody was able to neutralize 8 clade B viruses (n=16), 1 clade C virus (n=11), and 2 clade D viruses (n=6), thus placing it among the more broadly neutralizing anti-V3 antibodies described so far. Contrary to an initial report, results from our scanning mutagenesis of the V3 region suggest that mAb F425-B4e8 interacts primarily with the crown/tip of V3, notably Ile(309), Arg(315), and Phe(317). Despite the somewhat limited neutralization breadth of mAb F425-B4e8, the results presented here, along with analyses from other cross-neutralizing anti-V3 mAbs, may facilitate the template-based design of antigens that target V3 and permit neutralization of HIV-1 strains in which the V3 region is accessible to antibodies." @default.
- W1987291092 created "2016-06-24" @default.
- W1987291092 creator A5014886466 @default.
- W1987291092 creator A5034553895 @default.
- W1987291092 creator A5053451157 @default.
- W1987291092 creator A5058546353 @default.
- W1987291092 creator A5083761621 @default.
- W1987291092 date "2007-08-01" @default.
- W1987291092 modified "2023-09-26" @default.
- W1987291092 title "Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis" @default.
- W1987291092 cites W1503866863 @default.
- W1987291092 cites W1572744608 @default.
- W1987291092 cites W1576634738 @default.
- W1987291092 cites W1628484047 @default.
- W1987291092 cites W1768202295 @default.
- W1987291092 cites W1842798465 @default.
- W1987291092 cites W1911432365 @default.
- W1987291092 cites W1923989984 @default.
- W1987291092 cites W1925504181 @default.
- W1987291092 cites W1933773138 @default.
- W1987291092 cites W1942872605 @default.
- W1987291092 cites W1976595872 @default.
- W1987291092 cites W1980696330 @default.
- W1987291092 cites W1982794770 @default.
- W1987291092 cites W1989527063 @default.
- W1987291092 cites W1990159344 @default.
- W1987291092 cites W1991436594 @default.
- W1987291092 cites W1994322627 @default.
- W1987291092 cites W1995187084 @default.
- W1987291092 cites W1995355944 @default.
- W1987291092 cites W1996024886 @default.
- W1987291092 cites W1998987175 @default.
- W1987291092 cites W2002183278 @default.
- W1987291092 cites W2003146398 @default.
- W1987291092 cites W2008810418 @default.
- W1987291092 cites W2010521915 @default.
- W1987291092 cites W2011206581 @default.
- W1987291092 cites W2012072902 @default.
- W1987291092 cites W2015490314 @default.
- W1987291092 cites W2018161173 @default.
- W1987291092 cites W2019774346 @default.
- W1987291092 cites W2023346730 @default.
- W1987291092 cites W2023434411 @default.
- W1987291092 cites W2024977015 @default.
- W1987291092 cites W2026788309 @default.
- W1987291092 cites W2027054871 @default.
- W1987291092 cites W2034160159 @default.
- W1987291092 cites W2035178191 @default.
- W1987291092 cites W2036018115 @default.
- W1987291092 cites W2042655455 @default.
- W1987291092 cites W2048362048 @default.
- W1987291092 cites W2052006174 @default.
- W1987291092 cites W2055834697 @default.
- W1987291092 cites W2056493803 @default.
- W1987291092 cites W2056564693 @default.
- W1987291092 cites W2058632331 @default.
- W1987291092 cites W2059445854 @default.
- W1987291092 cites W2062947579 @default.
- W1987291092 cites W2063519195 @default.
- W1987291092 cites W2063561126 @default.
- W1987291092 cites W2071419268 @default.
- W1987291092 cites W2071905599 @default.
- W1987291092 cites W2071914798 @default.
- W1987291092 cites W2072901265 @default.
- W1987291092 cites W2073379847 @default.
- W1987291092 cites W2076789803 @default.
- W1987291092 cites W2077593092 @default.
- W1987291092 cites W2081392883 @default.
- W1987291092 cites W2082006283 @default.
- W1987291092 cites W2082734948 @default.
- W1987291092 cites W2083445427 @default.
- W1987291092 cites W2093251878 @default.
- W1987291092 cites W2093282128 @default.
- W1987291092 cites W2096497391 @default.
- W1987291092 cites W2099308199 @default.
- W1987291092 cites W2099576234 @default.
- W1987291092 cites W2110499527 @default.
- W1987291092 cites W2120653364 @default.
- W1987291092 cites W2121497936 @default.
- W1987291092 cites W2122936417 @default.
- W1987291092 cites W2124195126 @default.
- W1987291092 cites W2124445678 @default.
- W1987291092 cites W2124935744 @default.
- W1987291092 cites W2126979164 @default.
- W1987291092 cites W2127312553 @default.
- W1987291092 cites W2128055354 @default.
- W1987291092 cites W2141444589 @default.
- W1987291092 cites W2143029575 @default.
- W1987291092 cites W2145462968 @default.
- W1987291092 cites W2146704167 @default.
- W1987291092 cites W2147064797 @default.
- W1987291092 cites W2150001263 @default.
- W1987291092 cites W2157210912 @default.
- W1987291092 cites W2164094123 @default.
- W1987291092 cites W2164562004 @default.
- W1987291092 cites W2169201700 @default.
- W1987291092 cites W2172063653 @default.
- W1987291092 cites W2320356847 @default.