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• W1987296896 endingPage "1612" @default.
• W1987296896 startingPage "1593" @default.
• W1987296896 abstract "The members of the small heat shock protein (sHSP) family are molecular chaperones that play major roles in development, stress responses, and diseases, and have been envisioned as targets for therapy, particularly in cancer. The molecular mechanisms that regulate their transcription, in normal, stress, or pathological conditions, are characterized by extreme complexity and subtlety. Although historically linked to the heat shock transcription factors (HSFs), the stress-induced or developmental expression of the diverse members, including HSPB1/Hsp27/Hsp25, αA-crystallin/HSPB4, and αB-crystallin/HSPB5, relies on the combinatory effects of many transcription factors. Coupled with remarkably different cis-element architectures in the sHsp regulatory regions, they confer to each member its developmental expression or stress-inducibility. For example, multiple regulatory pathways coordinate the spatio-temporal expression of mouse αA-, αB-crystallin, and Hsp25 genes during lens development, through the action of master genes, like the large Maf family proteins and Pax6, but also HSF4. The inducibility of Hsp27 and αB-crystallin transcription by various stresses is exerted by HSF-dependent mechanisms, by which concomitant induction of Hsp27 and αB-crystallin expression is observed. In contrast, HSF-independent pathways can lead to αB-crystallin expression, but not to Hsp27 induction. Not surprisingly, deregulation of the expression of sHSP is associated with various pathologies, including cancer, neurodegenerative, or cardiac diseases. However, many questions remain to be addressed, and further elucidation of the developmental mechanisms of sHsp gene transcription might help to unravel the tissue- and stage-specific functions of this fascinating class of proteins, which might prove to be crucial for future therapeutic strategies. This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology." @default.
• W1987296896 created "2016-06-24" @default.
• W1987296896 creator A5017401234 @default.
• W1987296896 creator A5024658242 @default.
• W1987296896 creator A5083394465 @default.
• W1987296896 date "2012-10-01" @default.
• W1987296896 modified "2023-10-07" @default.
• W1987296896 title "Transcriptional regulation of small HSP—HSF1 and beyond" @default.
• W1987296896 cites W139428495 @default.
• W1987296896 cites W1433025566 @default.
• W1987296896 cites W1481246627 @default.
• W1987296896 cites W1481373594 @default.
• W1987296896 cites W1486179476 @default.
• W1987296896 cites W1499645177 @default.
• W1987296896 cites W1515983280 @default.
• W1987296896 cites W1544206819 @default.
• W1987296896 cites W1545156714 @default.
• W1987296896 cites W1569022805 @default.
• W1987296896 cites W1574972176 @default.
• W1987296896 cites W1583661311 @default.
• W1987296896 cites W1815018889 @default.
• W1987296896 cites W1905585974 @default.
• W1987296896 cites W1923039449 @default.
• W1987296896 cites W1933920814 @default.
• W1987296896 cites W1939195496 @default.
• W1987296896 cites W1963848932 @default.
• W1987296896 cites W1964224666 @default.
• W1987296896 cites W1964318436 @default.
• W1987296896 cites W1965190974 @default.
• W1987296896 cites W1966040297 @default.
• W1987296896 cites W1967269091 @default.
• W1987296896 cites W1967447574 @default.
• W1987296896 cites W1968800829 @default.
• W1987296896 cites W1968802798 @default.
• W1987296896 cites W1968820370 @default.
• W1987296896 cites W1969281472 @default.
• W1987296896 cites W1969900921 @default.
• W1987296896 cites W1971090593 @default.
• W1987296896 cites W1971338308 @default.
• W1987296896 cites W1972233647 @default.
• W1987296896 cites W1972382471 @default.
• W1987296896 cites W1972604812 @default.
• W1987296896 cites W1972836153 @default.
• W1987296896 cites W1972975729 @default.
• W1987296896 cites W1973413376 @default.
• W1987296896 cites W1973955621 @default.
• W1987296896 cites W1975195662 @default.
• W1987296896 cites W1976158943 @default.
• W1987296896 cites W1976312884 @default.
• W1987296896 cites W1976727208 @default.
• W1987296896 cites W1977199185 @default.
• W1987296896 cites W1978017921 @default.
• W1987296896 cites W1979843639 @default.
• W1987296896 cites W1980473808 @default.
• W1987296896 cites W1980898030 @default.
• W1987296896 cites W1981217349 @default.
• W1987296896 cites W1981276526 @default.
• W1987296896 cites W1981686096 @default.
• W1987296896 cites W1981982168 @default.
• W1987296896 cites W1982101727 @default.
• W1987296896 cites W1982425303 @default.
• W1987296896 cites W1982511318 @default.
• W1987296896 cites W1982561342 @default.
• W1987296896 cites W1983761436 @default.
• W1987296896 cites W1984532887 @default.
• W1987296896 cites W1985549353 @default.
• W1987296896 cites W1986819159 @default.
• W1987296896 cites W1987154664 @default.
• W1987296896 cites W1987480357 @default.
• W1987296896 cites W1987642944 @default.
• W1987296896 cites W1987657904 @default.
• W1987296896 cites W1988372844 @default.
• W1987296896 cites W1990238941 @default.
• W1987296896 cites W1991320122 @default.
• W1987296896 cites W1991631628 @default.
• W1987296896 cites W1992015519 @default.
• W1987296896 cites W1992624136 @default.
• W1987296896 cites W1993214904 @default.
• W1987296896 cites W1994090435 @default.
• W1987296896 cites W1994445799 @default.
• W1987296896 cites W1996309823 @default.
• W1987296896 cites W1996781482 @default.
• W1987296896 cites W1997016405 @default.
• W1987296896 cites W1998277976 @default.
• W1987296896 cites W2000286622 @default.
• W1987296896 cites W2003324646 @default.
• W1987296896 cites W2003798462 @default.
• W1987296896 cites W2004998976 @default.
• W1987296896 cites W2005199468 @default.
• W1987296896 cites W2005686852 @default.
• W1987296896 cites W2007619482 @default.
• W1987296896 cites W2008536823 @default.
• W1987296896 cites W2009578263 @default.
• W1987296896 cites W2010855976 @default.
• W1987296896 cites W2012015460 @default.
• W1987296896 cites W2012998468 @default.
• W1987296896 cites W2013575559 @default.
• W1987296896 cites W2014067310 @default.

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