Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987305883> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1987305883 endingPage "1083" @default.
- W1987305883 startingPage "1081" @default.
- W1987305883 abstract "The diastereoselective alkylation of the chiral Evans intermediate 2 with 1-iodo-2-pentyne (3) gives the oxazolidinone 4. Titanium alkoxide-catalysed cleavage yields the ethyl ester 5, which is used to acylate dimethyl methanephosphonate to the chiral phosphonate 6. The optical purity of phosphonate 6 is checked by separation on a chiral HPLC column and by conversion into the bromo ketone 8, an intermediate for the prostacyclin analogue ZK 96480. Einfache Darstellung von Dimethyl-[(3S)-3-methyl-2-oxo-5-octinyl]phosphonat Die diastereoselektive Alkylierung des chiralen Evans-Intermediates 2 mit 1-Iod-2-pentin (3) gibt das Oxazolidinon 4. Titanalkoxid-katalysierte Spaltung des Produktes zum Ethylester 5 und Acylierung von Methanphosphonsäure-dimethylester ergibt das chirale Phosphonat 6. Die optische Reinheit des Phosphonates 6 wird durch Trennung der Enantiomeren an einer chiralen HPLC-Säule und durch Umsetzung zum Bromketon 8 – einem Zwischenprodukt für das Prostacylin-Analoge ZK 96480 – belegt." @default.
- W1987305883 created "2016-06-24" @default.
- W1987305883 creator A5001069613 @default.
- W1987305883 creator A5028299773 @default.
- W1987305883 creator A5072917336 @default.
- W1987305883 date "1989-11-13" @default.
- W1987305883 modified "2023-10-16" @default.
- W1987305883 title "Convenient Preparation of Dimethyl [(3S)-3-Methyl-2-oxo-5-octynyl]-phosphonate" @default.
- W1987305883 cites W1969069937 @default.
- W1987305883 cites W1979972122 @default.
- W1987305883 cites W2018311235 @default.
- W1987305883 cites W2026339104 @default.
- W1987305883 cites W2035652731 @default.
- W1987305883 cites W2043407516 @default.
- W1987305883 cites W2043966259 @default.
- W1987305883 cites W2062966354 @default.
- W1987305883 cites W2070419964 @default.
- W1987305883 cites W2075226800 @default.
- W1987305883 cites W2079096338 @default.
- W1987305883 cites W2081747335 @default.
- W1987305883 cites W2090350205 @default.
- W1987305883 cites W2094761711 @default.
- W1987305883 cites W2139815907 @default.
- W1987305883 cites W2323189479 @default.
- W1987305883 cites W2408853165 @default.
- W1987305883 cites W3005470321 @default.
- W1987305883 cites W4210978842 @default.
- W1987305883 doi "https://doi.org/10.1002/jlac.198919890272" @default.
- W1987305883 hasPublicationYear "1989" @default.
- W1987305883 type Work @default.
- W1987305883 sameAs 1987305883 @default.
- W1987305883 citedByCount "20" @default.
- W1987305883 countsByYear W19873058832014 @default.
- W1987305883 countsByYear W19873058832019 @default.
- W1987305883 crossrefType "journal-article" @default.
- W1987305883 hasAuthorship W1987305883A5001069613 @default.
- W1987305883 hasAuthorship W1987305883A5028299773 @default.
- W1987305883 hasAuthorship W1987305883A5072917336 @default.
- W1987305883 hasConcept C161790260 @default.
- W1987305883 hasConcept C164361826 @default.
- W1987305883 hasConcept C178790620 @default.
- W1987305883 hasConcept C185592680 @default.
- W1987305883 hasConcept C2777626080 @default.
- W1987305883 hasConcept C2777738585 @default.
- W1987305883 hasConcept C71240020 @default.
- W1987305883 hasConceptScore W1987305883C161790260 @default.
- W1987305883 hasConceptScore W1987305883C164361826 @default.
- W1987305883 hasConceptScore W1987305883C178790620 @default.
- W1987305883 hasConceptScore W1987305883C185592680 @default.
- W1987305883 hasConceptScore W1987305883C2777626080 @default.
- W1987305883 hasConceptScore W1987305883C2777738585 @default.
- W1987305883 hasConceptScore W1987305883C71240020 @default.
- W1987305883 hasIssue "11" @default.
- W1987305883 hasLocation W19873058831 @default.
- W1987305883 hasOpenAccess W1987305883 @default.
- W1987305883 hasPrimaryLocation W19873058831 @default.
- W1987305883 hasRelatedWork W1907113514 @default.
- W1987305883 hasRelatedWork W1993450165 @default.
- W1987305883 hasRelatedWork W2154265923 @default.
- W1987305883 hasRelatedWork W2342858580 @default.
- W1987305883 hasRelatedWork W2396629880 @default.
- W1987305883 hasRelatedWork W2789704176 @default.
- W1987305883 hasRelatedWork W2949153590 @default.
- W1987305883 hasRelatedWork W2949293959 @default.
- W1987305883 hasRelatedWork W2949668585 @default.
- W1987305883 hasRelatedWork W2951494344 @default.
- W1987305883 hasVolume "1989" @default.
- W1987305883 isParatext "false" @default.
- W1987305883 isRetracted "false" @default.
- W1987305883 magId "1987305883" @default.
- W1987305883 workType "article" @default.