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- W1987326814 endingPage "3161" @default.
- W1987326814 startingPage "3161" @default.
- W1987326814 abstract "Bone defects requiring grafts to promote healing are frequently occurring and costly problems in health care. Chitosan, a biodegradable, naturally occurring polymer, has drawn considerable attention in recent years as a scaffolding material in tissue engineering and regenerative medicine. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of mineralized bone matrix. In this review, we discuss the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration. We present common methods for fabrication and characterization of chitosan scaffolds, and discuss the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitosan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration. Finally, we highlight recent advances in the development of chitosan-based scaffolds with enhanced bone regeneration capability." @default.
- W1987326814 created "2016-06-24" @default.
- W1987326814 creator A5026123890 @default.
- W1987326814 creator A5082164835 @default.
- W1987326814 date "2014-01-01" @default.
- W1987326814 modified "2023-10-18" @default.
- W1987326814 title "Chitosan-based scaffolds for bone tissue engineering" @default.
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