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- W1987327280 abstract "Background: The liver plays not only a central role in coagulation but also closely correlates with qualitative and quantitative deficiency of platelets. Chronic liver disease (CLD), particularly in the end stage, is characterized by disorders of bleeding and coagulation abnormalities. Aim: (i) To determine the coagulation profile and platelet count in the patients of CLD and (ii) to determine the relationship between coagulation profile and severity of CLD in these patients. Method: Sixty-four adult patients of CLD admitted in the Department of Medicine, Gauhati Medical College over a period of 6 months were studied, and prothrombine time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), and platelet counts were determined in these patients. Liver disease severity was graded using Child’s score. Result: Alcohol (73.43%) was found to be the most common etiology for CLD in the study. Males were affected more than female (M:F = 8:1). Forty-four (68.75%) patients had increased PT, and 40 (62.5%) patients had increased APTT. Forty-one (64.06%) had increased INR, and 36 (56.25%) patients had decreased platelet count. Mean PT, mean APTT, mean INR, and mean platelet count in the total patients were found to be 18.6, 41.80, 1.67, and 127,905, respectively, while in Child C grade, mean PT, mean APTT, mean INR, and mean platelet count were found to be 24.4, 47.62, 2.15, and 110,538, respectively. Conclusion: Abnormalities in hemostasis is fairly common in CLD. The PT, APTT, and INR abnormalities have a positive correlation with severity of disease. However, qualitative platelet abnormality was also detected in CLD. Therefore, qualitative tests for platelet functions are necessary to arrive at a definite conclusion regarding role of platelets. 34" @default.
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- W1987327280 date "2012-03-01" @default.
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- W1987327280 title "33 A STUDY ON COAGULATION PROFILE IN PATIENTS OF CHRONIC LIVER DISEASE" @default.
- W1987327280 doi "https://doi.org/10.1016/s0973-6883(12)60034-6" @default.
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