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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987328305> ?p ?o ?g. }

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• W1987328305 abstract "Kaempferia galanga L. (Zingiberaceae) is an aromatic herb and a popular spice used as a condiment in Asian cuisine. The ethanol extract of the dried plant and its successive four subfractions were investigated on zebrafish model by quantitative endogenous alkaline phosphatase assay. Both n-hexane and ethyl acetate fractions had antiangiogenic activity, and two major active components (trans-ethyl p-methoxycinnamate and kaempferol) showed potent antiangiogenic effects on wild-type zebrafish. Because of its much stronger effect and no antiangiogenic activity reported, trans-ethyl p-methoxycinnamate was further investigated for its action mechanism. It dose dependently inhibited vessel formation on both wild- and Tg(fli1a:EGFP)y1-type zebrafish embryos. The semiquantitative reverse transcription polymerase chain reaction assay suggested that trans-ethyl p-methoxycinnamate affects multiple molecular targets related to angiogenesis. In vitro, it specifically inhibited the migration and tube formation of human umbilical vein endothelial cells. In vivo, it could block bFGF-induced vessel formation on Matrigel plug assay." @default.
• W1987328305 created "2016-06-24" @default.
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• W1987328305 date "2012-11-05" @default.
• W1987328305 modified "2023-10-16" @default.
• W1987328305 title "Antiangiogenic Effects and Mechanisms of <i>trans</i>-Ethyl <i>p</i>-Methoxycinnamate from <i>Kaempferia galanga</i> L." @default.
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• W1987328305 doi "https://doi.org/10.1021/jf304169j" @default.
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