Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987333447> ?p ?o ?g. }
- W1987333447 endingPage "7848" @default.
- W1987333447 startingPage "7848" @default.
- W1987333447 abstract "Major challenges in the development of effective stimuli-responsive nanogels as targeted drug and gene delivery carriers are to improve biocompatibility, stability, and controlled release during systemic circulation. In this work, biofunctional nanogels based on copolymers of poly(N-2-hydroxyethyl acrylamide) (polyHEAA) and acrylic acid (AA) with controlled size and morphology are synthesized using an inverse-microemulsion free-radical polymerization method. The chemical composition, size, swelling behavior, physical stability, and antifouling ability of the poly(HEAA/AA) nanogels are characterized by FTIR, dynamic light scattering, and atomic force microscopy. The cell viability and uptake of the nanogels are evaluated under physiological conditions. The controlled release of drugs in the nanogels is measured in both aqueous media and cell culture upon changes in pH and salt concentration. The poly(HEAA/AA) nanogels exhibit both superlow fouling ability to resist nonspecific protein adsorption and ultrastability to keep their hydrodynamic sizes unchanged in 100% human blood plasma for 30 days in vitro. The controlled release of Rhodamine 6G encapsulated in poly(HEAA/AA) nanogels is demonstrated at a low pH and high salt concentration. More importantly, the conjugation of transferrin with poly(HEAA/AA) nanogels allows the uptake of nanogels by SH-SY5Y cells and triggering of intracellular drug release, while not inducing cytotoxicity to cells similar to innate cell viability. HEAA/AA-based nanogels hold great potential as drug delivery carriers in vivo, because they integrate ultrastability, superlow fouling ability, and environmental-responsive controlled release property into one chemical entity." @default.
- W1987333447 created "2016-06-24" @default.
- W1987333447 creator A5001285938 @default.
- W1987333447 creator A5005303316 @default.
- W1987333447 creator A5024000881 @default.
- W1987333447 creator A5025483246 @default.
- W1987333447 creator A5034519027 @default.
- W1987333447 creator A5062023507 @default.
- W1987333447 creator A5084580172 @default.
- W1987333447 creator A5087128361 @default.
- W1987333447 date "2012-01-01" @default.
- W1987333447 modified "2023-10-16" @default.
- W1987333447 title "Synthesis and characterization of pH-sensitive poly(N-2-hydroxyethyl acrylamide)–acrylic acid (poly(HEAA/AA)) nanogels with antifouling protection for controlled release" @default.
- W1987333447 cites W1610965833 @default.
- W1987333447 cites W1965063770 @default.
- W1987333447 cites W1965097716 @default.
- W1987333447 cites W1968947842 @default.
- W1987333447 cites W1971623447 @default.
- W1987333447 cites W1980122435 @default.
- W1987333447 cites W1991605349 @default.
- W1987333447 cites W1992485826 @default.
- W1987333447 cites W1995353935 @default.
- W1987333447 cites W2001199187 @default.
- W1987333447 cites W2004065690 @default.
- W1987333447 cites W2007084683 @default.
- W1987333447 cites W2007205934 @default.
- W1987333447 cites W2011366287 @default.
- W1987333447 cites W2012806326 @default.
- W1987333447 cites W2013236964 @default.
- W1987333447 cites W2013984845 @default.
- W1987333447 cites W2014987477 @default.
- W1987333447 cites W2023962452 @default.
- W1987333447 cites W2028091603 @default.
- W1987333447 cites W2030841219 @default.
- W1987333447 cites W2032683682 @default.
- W1987333447 cites W2036289383 @default.
- W1987333447 cites W2040694465 @default.
- W1987333447 cites W2042883991 @default.
- W1987333447 cites W2048808551 @default.
- W1987333447 cites W2049059816 @default.
- W1987333447 cites W2049975923 @default.
- W1987333447 cites W2057084135 @default.
- W1987333447 cites W2060713279 @default.
- W1987333447 cites W2062299552 @default.
- W1987333447 cites W2069661192 @default.
- W1987333447 cites W2069870790 @default.
- W1987333447 cites W2070986221 @default.
- W1987333447 cites W2071662504 @default.
- W1987333447 cites W2075277486 @default.
- W1987333447 cites W2088410504 @default.
- W1987333447 cites W2099747044 @default.
- W1987333447 cites W2099799558 @default.
- W1987333447 cites W2107214272 @default.
- W1987333447 cites W2107322387 @default.
- W1987333447 cites W2108165319 @default.
- W1987333447 cites W2129637849 @default.
- W1987333447 cites W2142743818 @default.
- W1987333447 cites W2150918607 @default.
- W1987333447 cites W2166385048 @default.
- W1987333447 cites W2171868298 @default.
- W1987333447 doi "https://doi.org/10.1039/c2sm25861g" @default.
- W1987333447 hasPublicationYear "2012" @default.
- W1987333447 type Work @default.
- W1987333447 sameAs 1987333447 @default.
- W1987333447 citedByCount "75" @default.
- W1987333447 countsByYear W19873334472013 @default.
- W1987333447 countsByYear W19873334472014 @default.
- W1987333447 countsByYear W19873334472015 @default.
- W1987333447 countsByYear W19873334472016 @default.
- W1987333447 countsByYear W19873334472017 @default.
- W1987333447 countsByYear W19873334472018 @default.
- W1987333447 countsByYear W19873334472019 @default.
- W1987333447 countsByYear W19873334472020 @default.
- W1987333447 countsByYear W19873334472021 @default.
- W1987333447 countsByYear W19873334472022 @default.
- W1987333447 countsByYear W19873334472023 @default.
- W1987333447 crossrefType "journal-article" @default.
- W1987333447 hasAuthorship W1987333447A5001285938 @default.
- W1987333447 hasAuthorship W1987333447A5005303316 @default.
- W1987333447 hasAuthorship W1987333447A5024000881 @default.
- W1987333447 hasAuthorship W1987333447A5025483246 @default.
- W1987333447 hasAuthorship W1987333447A5034519027 @default.
- W1987333447 hasAuthorship W1987333447A5062023507 @default.
- W1987333447 hasAuthorship W1987333447A5084580172 @default.
- W1987333447 hasAuthorship W1987333447A5087128361 @default.
- W1987333447 hasConcept C13965031 @default.
- W1987333447 hasConcept C15920480 @default.
- W1987333447 hasConcept C171250308 @default.
- W1987333447 hasConcept C178790620 @default.
- W1987333447 hasConcept C185592680 @default.
- W1987333447 hasConcept C188027245 @default.
- W1987333447 hasConcept C192562407 @default.
- W1987333447 hasConcept C2779402116 @default.
- W1987333447 hasConcept C2780503075 @default.
- W1987333447 hasConcept C2780841128 @default.
- W1987333447 hasConcept C41625074 @default.
- W1987333447 hasConcept C521977710 @default.
- W1987333447 hasConcept C55493867 @default.