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• W1987335324 abstract "Three novel structural series of C-4″ modified azithromycin analogs with two amide groups, which were connected by different alkyl linkage, were designed, prepared and evaluated for their in vitro antibacterial activity against seven phenotypes of respiratory pathogens. Among them, 7d, 8j and 9j, as representatives of corresponding series, exhibited remarkably improved activity against erythromycin-resistant Streptococcus pneumoniae expressing the erm gene, the mef gene, and the erm and mef genes. In addition, 7a–c, 7f–h, 7j, 8d, 8g, 8i, 9a–b and 9i displayed favorable efficacy against erythromycin-resistant S. pneumoniae A22072 expressing the mef gene." @default.
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• W1987335324 date "2011-10-01" @default.
• W1987335324 modified "2023-10-16" @default.
• W1987335324 title "Novel C-4″ modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: The synthesis and antimicrobial evaluation" @default.
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• W1987335324 doi "https://doi.org/10.1016/j.ejmech.2011.08.001" @default.
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