Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987339923> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1987339923 endingPage "269" @default.
- W1987339923 startingPage "260" @default.
- W1987339923 abstract "The short- and long-term effects of cyclic AMP analogues and phosphodiesterase inhibitors on phosphatidylcholine biosynthesis in monolayer cultures of rat hepatocytes were investigated. All the compounds tested produced an inhibition of phosphatidylcholine biosynthesis for up to 6 h after addition to the hepatocyte medium. The reduced rate of lipid synthesis was a function of the concentration of cyclic AMP analogue and was independent of the concentration of choline in the medium. The proportion of choline oxidized to betaine was relatively unaffected. Choline was incorporated into hepatocytes by saturable and non-saturable mechanisms. Although the various cAMP analogues had different effects on choline uptake, chlorophenylthio-cAMP reduced uptake of choline by 28% for cells treated for 1.5–15 h. This analogue lowered the Vmax of the saturable component of choline transport by 3.6-fold. Prolonged incubation of the hepatocytes with cAMP analogues resulted in a reversal of the inhibition of phosphatidylcholine synthesis. After 15 h all the compounds tested stimulated the relative incorporation of [methyl-3H]choline into phosphatidylcholine. For hepatocytes incubated with chlorophenylthio-cAMP for 14–16 h, there was a 2.8-fold stimulation of the rate of phosphatidylcholine synthesis. The enzymes responsible for the conversion of choline into phosphatidylcholine were examined at various times after addition of the chlorophenylthio-cAMP to the hepatocyte medium. The reduced synthesis of phosphatidylcholine strongly correlated with inhibition of CTP:phosphocholine cytidylyltransferase activity. After 12 h of treatment with the analogue, the relative inhibition of the cytidylyltransferase activity was reversed." @default.
- W1987339923 created "2016-06-24" @default.
- W1987339923 creator A5037349846 @default.
- W1987339923 creator A5073998071 @default.
- W1987339923 creator A5084875396 @default.
- W1987339923 date "1982-11-01" @default.
- W1987339923 modified "2023-10-14" @default.
- W1987339923 title "Prolonged effects of cyclic AMP analogues of phosphatidylcholine biosynthesis in cultured rat hepatocytes" @default.
- W1987339923 cites W1520548658 @default.
- W1987339923 cites W1549058817 @default.
- W1987339923 cites W1604863183 @default.
- W1987339923 cites W1609121587 @default.
- W1987339923 cites W1615873781 @default.
- W1987339923 cites W168008062 @default.
- W1987339923 cites W1921593426 @default.
- W1987339923 cites W1988320170 @default.
- W1987339923 cites W2009483599 @default.
- W1987339923 cites W2011789189 @default.
- W1987339923 cites W2012808817 @default.
- W1987339923 cites W2013650172 @default.
- W1987339923 cites W2019455758 @default.
- W1987339923 cites W2022674921 @default.
- W1987339923 cites W2025716364 @default.
- W1987339923 cites W2030903558 @default.
- W1987339923 cites W2081970565 @default.
- W1987339923 cites W2095373155 @default.
- W1987339923 cites W2131241064 @default.
- W1987339923 cites W2168526937 @default.
- W1987339923 cites W2322438766 @default.
- W1987339923 cites W2414587558 @default.
- W1987339923 cites W2869189 @default.
- W1987339923 cites W4293247451 @default.
- W1987339923 doi "https://doi.org/10.1016/0005-2760(82)90243-0" @default.
- W1987339923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6185153" @default.
- W1987339923 hasPublicationYear "1982" @default.
- W1987339923 type Work @default.
- W1987339923 sameAs 1987339923 @default.
- W1987339923 citedByCount "45" @default.
- W1987339923 crossrefType "journal-article" @default.
- W1987339923 hasAuthorship W1987339923A5037349846 @default.
- W1987339923 hasAuthorship W1987339923A5073998071 @default.
- W1987339923 hasAuthorship W1987339923A5084875396 @default.
- W1987339923 hasConcept C181199279 @default.
- W1987339923 hasConcept C185592680 @default.
- W1987339923 hasConcept C202751555 @default.
- W1987339923 hasConcept C2776200302 @default.
- W1987339923 hasConcept C2776330855 @default.
- W1987339923 hasConcept C2776923060 @default.
- W1987339923 hasConcept C2777248517 @default.
- W1987339923 hasConcept C2778918659 @default.
- W1987339923 hasConcept C2780601828 @default.
- W1987339923 hasConcept C2781123555 @default.
- W1987339923 hasConcept C41625074 @default.
- W1987339923 hasConcept C553450214 @default.
- W1987339923 hasConcept C55493867 @default.
- W1987339923 hasConcept C86803240 @default.
- W1987339923 hasConceptScore W1987339923C181199279 @default.
- W1987339923 hasConceptScore W1987339923C185592680 @default.
- W1987339923 hasConceptScore W1987339923C202751555 @default.
- W1987339923 hasConceptScore W1987339923C2776200302 @default.
- W1987339923 hasConceptScore W1987339923C2776330855 @default.
- W1987339923 hasConceptScore W1987339923C2776923060 @default.
- W1987339923 hasConceptScore W1987339923C2777248517 @default.
- W1987339923 hasConceptScore W1987339923C2778918659 @default.
- W1987339923 hasConceptScore W1987339923C2780601828 @default.
- W1987339923 hasConceptScore W1987339923C2781123555 @default.
- W1987339923 hasConceptScore W1987339923C41625074 @default.
- W1987339923 hasConceptScore W1987339923C553450214 @default.
- W1987339923 hasConceptScore W1987339923C55493867 @default.
- W1987339923 hasConceptScore W1987339923C86803240 @default.
- W1987339923 hasIssue "2" @default.
- W1987339923 hasLocation W19873399231 @default.
- W1987339923 hasLocation W19873399232 @default.
- W1987339923 hasOpenAccess W1987339923 @default.
- W1987339923 hasPrimaryLocation W19873399231 @default.
- W1987339923 hasRelatedWork W1975571564 @default.
- W1987339923 hasRelatedWork W1987339923 @default.
- W1987339923 hasRelatedWork W1995477876 @default.
- W1987339923 hasRelatedWork W2004013202 @default.
- W1987339923 hasRelatedWork W2031498465 @default.
- W1987339923 hasRelatedWork W2210370840 @default.
- W1987339923 hasRelatedWork W2296678954 @default.
- W1987339923 hasRelatedWork W2768787369 @default.
- W1987339923 hasRelatedWork W2949840475 @default.
- W1987339923 hasRelatedWork W1991106453 @default.
- W1987339923 hasVolume "713" @default.
- W1987339923 isParatext "false" @default.
- W1987339923 isRetracted "false" @default.
- W1987339923 magId "1987339923" @default.
- W1987339923 workType "article" @default.