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• W1987339939 endingPage "2531" @default.
• W1987339939 startingPage "2522" @default.
• W1987339939 abstract "The eukaryotic cell cycle is driven by a cascade of cyclins and kinase partners including the G1 cyclin Cln3p in yeast. As the first step in this cascade, Cln3p is uniquely positioned to determine the critical growth-rate threshold for division. To analyze factors regulating CLN3 expression, we identified a short upstream open reading frame (uORF) in the 5' leader of CLN3 mRNA as a translational control element. This control element is critical for the growth-dependent regulation of Cln3p synthesis because it specifically represses CLN3 expression during conditions of diminished protein synthesis or slow growth. Inactivation of the uORF accelerates the completion of Start and entry into the cell cycle suggesting that translational regulation of CLN3 provides a mechanism coupling cell growth and division." @default.
• W1987339939 created "2016-06-24" @default.
• W1987339939 creator A5042503296 @default.
• W1987339939 creator A5043269990 @default.
• W1987339939 date "1997-10-01" @default.
• W1987339939 modified "2023-10-14" @default.
• W1987339939 title "Coupling of cell division to cell growth by translational control of the G₁ cyclin <i>CLN3</i> in yeast" @default.
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• W1987339939 doi "https://doi.org/10.1101/gad.11.19.2522" @default.
• W1987339939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316559" @default.
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