Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987347227> ?p ?o ?g. }
- W1987347227 endingPage "196" @default.
- W1987347227 startingPage "180" @default.
- W1987347227 abstract "Bone marrow-enhancing factor (B-EF) is the spontaneous product of whole bone marrow cells cultured in serum-free medium for a short term (24–48 hr). The factor is prepared by ultrafiltration of BMC supernates to yield a preparation with a MW of greater than 10,000. Production of the factor is not dependent upon antigenic or mitogenic stimulation of BMC, but is inhibited by treatment of BMC with cycloheximide. B-EF augments the in vitro primary PFC response to SRBC, as well as in vitro secondary IgM and IgG PFC responses to SRBC. Enhancement by B-EF is antigen dependent, genetically nonrestricted, and maximal when present at the initiation of culture. B-EF cannot induce a polyclonal antibody response like the polyclonal activator LPS. B-EF is directly mitogenic for thymocytes, bone marrow, and whole spleen cells, but fails to act as a costimulator of thymocyte proliferation in the presence of Con A. B-EF cannot support the growth of the IL-2-dependent cell line CTLL-2. Since B-EF has not been purified, the supernatant may contain more than one activity. The factor is heat labile at 65 °C and is sensitive to enzymatic digestion with trypsin and neuraminidase; this implies that B-EF may be a glycoprotein." @default.
- W1987347227 created "2016-06-24" @default.
- W1987347227 creator A5033603252 @default.
- W1987347227 creator A5070326200 @default.
- W1987347227 date "1978-03-01" @default.
- W1987347227 modified "2023-09-23" @default.
- W1987347227 title "Lymphocytic functions acted on by immunoregulatory cytokines significance of the cell cycle" @default.
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