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- W1987348511 abstract "Abstract Purpose To extend observations on intra‐renal oxygenation with blood oxygen level‐dependent (BOLD) MRI in human and rats to mouse kidneys imaged with a human whole‐body scanner. Materials and Methods Renal BOLD MRI studies were performed on a 3.0T scanner using a multiple gradient‐echo (mGRE) sequence with a custom‐designed 2.0‐cm surface coil to acquire six T 2 *‐weighted images in mice ( N = 8) at an in‐plane resolution of 156 × 156 μm 2 . BOLD MRI data were obtained before and after administration of furosemide (10 mg/kg intravenously [i.v.]). Results The mean weight of eight mice was 24.6 ± 1.0 g. The baseline renal R 2 * (mean ± standard error [SE]) was 28.6 ± 2.1 seconds –1 in the renal cortex (CO), 35.4 ± 2.2 in the outer medulla (OM), and 21.2 ± 2.1 seconds –1 in the inner medulla (IM). The BOLD response to furosemide (ΔR 2 *) was 4.1 ± 1.4 in the CO, 10.1 ± 2.1 seconds –1 in the OM, and 3.4 ± 0.8 seconds –1 in the IM in mice. Conclusion Intrarenal BOLD MR images with sufficiently high resolution can be obtained on a human whole‐body scanner when combined with a small receiver coil to allow studies in mice. Both baseline R 2 * and ΔR 2 * values following administration of furosemide were consistent with previous experience in humans and rats. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc." @default.
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- W1987348511 date "2007-02-05" @default.
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- W1987348511 title "Evaluation of intrarenal oxygenation in mice by BOLD MRI on a 3.0T human whole-body scanner" @default.
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- W1987348511 doi "https://doi.org/10.1002/jmri.20841" @default.
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