FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987349679> ?p ?o ?g. }

• W1987349679 endingPage "420" @default.
• W1987349679 startingPage "416" @default.
• W1987349679 abstract "Cells of the immune system are unique among normal somatic cells in that they have the capacity to upregulate the telomere-extending enzyme, telomerase, albeit in a precisely controlled fashion. Kinetic analysis of telomerase activity in long-term T cell cultures has documented that the high level of telomerase induced in concert with activation reaches a peak at 3–5 days, then declines by 3 weeks. The process is recapitulated during secondary antigenic stimulation, but by the third, and all subsequent stimulations in vitro, CD8 T cells are unable to upregulate telomerase. Cell division in the absence of telomerase activity results in progressive telomere shortening, and ultimately, the DNA damage/cell cycle arrest that is signaled by critically short telomeres. Cultures of senescent CD8 T cells show altered cytokine patterns, resistance to apoptosis, and absence of expression of the CD28 costimulatory receptor. CD8 T cells with these and other features of replicative senescence accumulate progressively with age, and at an accelerated rate, during chronic infection with HIV-1. Clinical studies have shown that high proportions of CD8 T cells with the senescent phenotype correlate with several deleterious physiologic outcomes, including poor vaccine responses, bone loss, and increased proinflammatory cytokines. CD8+CD28− T cells have also been shown to exert suppressive activity on other immune cells. Based on the central role of telomere shortening in the replicative senescence program, we are developing several telomerase-based approaches as potential immunoenhancing treatments for aging and HIV disease. Gene therapy of HIV-specific CD8 T cells with the telomerase catalytic component (hTERT) results in enhanced proliferative capacity, increased anti-viral functions, and a delay in the loss of CD28 expression, with no changes in karyotype or growth kinetics. These proof-of-principle studies have led to screening for pharmacological approaches that might mimic the gene therapy effects, in a more clinically suitable formulation." @default.
• W1987349679 created "2016-06-24" @default.
• W1987349679 creator A5012688898 @default.
• W1987349679 date "2007-05-01" @default.
• W1987349679 modified "2023-09-24" @default.
• W1987349679 title "Telomerase induction in T cells: A cure for aging and disease?" @default.
• W1987349679 cites W1495069682 @default.
• W1987349679 cites W1524904345 @default.
• W1987349679 cites W1576064052 @default.
• W1987349679 cites W1684345377 @default.
• W1987349679 cites W1764386432 @default.
• W1987349679 cites W1891679949 @default.
• W1987349679 cites W1942855296 @default.
• W1987349679 cites W1972315079 @default.
• W1987349679 cites W1973076242 @default.
• W1987349679 cites W1973712699 @default.
• W1987349679 cites W1974252673 @default.
• W1987349679 cites W1976789091 @default.
• W1987349679 cites W1978436252 @default.
• W1987349679 cites W1988707875 @default.
• W1987349679 cites W1990331651 @default.
• W1987349679 cites W1994688157 @default.
• W1987349679 cites W2000115978 @default.
• W1987349679 cites W2000747219 @default.
• W1987349679 cites W2001733842 @default.
• W1987349679 cites W2006577998 @default.
• W1987349679 cites W2016458729 @default.
• W1987349679 cites W2035852466 @default.
• W1987349679 cites W2037915406 @default.
• W1987349679 cites W2052361881 @default.
• W1987349679 cites W2052656918 @default.
• W1987349679 cites W2063190780 @default.
• W1987349679 cites W2076566491 @default.
• W1987349679 cites W2089244708 @default.
• W1987349679 cites W2093500425 @default.
• W1987349679 cites W2101881039 @default.
• W1987349679 cites W2108482850 @default.
• W1987349679 cites W2112721427 @default.
• W1987349679 cites W2117623957 @default.
• W1987349679 cites W2118102816 @default.
• W1987349679 cites W2125229907 @default.
• W1987349679 cites W2142170111 @default.
• W1987349679 cites W2160352261 @default.
• W1987349679 cites W2408102417 @default.
• W1987349679 doi "https://doi.org/10.1016/j.exger.2006.11.005" @default.
• W1987349679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1913844" @default.
• W1987349679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17182206" @default.
• W1987349679 hasPublicationYear "2007" @default.
• W1987349679 type Work @default.
• W1987349679 sameAs 1987349679 @default.
• W1987349679 citedByCount "74" @default.
• W1987349679 countsByYear W19873496792012 @default.
• W1987349679 countsByYear W19873496792013 @default.
• W1987349679 countsByYear W19873496792014 @default.
• W1987349679 countsByYear W19873496792015 @default.
• W1987349679 countsByYear W19873496792016 @default.
• W1987349679 countsByYear W19873496792017 @default.
• W1987349679 countsByYear W19873496792018 @default.
• W1987349679 countsByYear W19873496792019 @default.
• W1987349679 countsByYear W19873496792020 @default.
• W1987349679 countsByYear W19873496792021 @default.
• W1987349679 countsByYear W19873496792022 @default.
• W1987349679 countsByYear W19873496792023 @default.
• W1987349679 crossrefType "journal-article" @default.
• W1987349679 hasAuthorship W1987349679A5012688898 @default.
• W1987349679 hasBestOaLocation W19873496792 @default.
• W1987349679 hasConcept C104317684 @default.
• W1987349679 hasConcept C125593758 @default.
• W1987349679 hasConcept C148125776 @default.
• W1987349679 hasConcept C154317977 @default.
• W1987349679 hasConcept C164027704 @default.
• W1987349679 hasConcept C167672396 @default.
• W1987349679 hasConcept C177336024 @default.
• W1987349679 hasConcept C202751555 @default.
• W1987349679 hasConcept C203014093 @default.
• W1987349679 hasConcept C2776090121 @default.
• W1987349679 hasConcept C2776914184 @default.
• W1987349679 hasConcept C502942594 @default.
• W1987349679 hasConcept C522857546 @default.
• W1987349679 hasConcept C54355233 @default.
• W1987349679 hasConcept C86803240 @default.
• W1987349679 hasConcept C8891405 @default.
• W1987349679 hasConcept C94581717 @default.
• W1987349679 hasConcept C95444343 @default.
• W1987349679 hasConceptScore W1987349679C104317684 @default.
• W1987349679 hasConceptScore W1987349679C125593758 @default.
• W1987349679 hasConceptScore W1987349679C148125776 @default.
• W1987349679 hasConceptScore W1987349679C154317977 @default.
• W1987349679 hasConceptScore W1987349679C164027704 @default.
• W1987349679 hasConceptScore W1987349679C167672396 @default.
• W1987349679 hasConceptScore W1987349679C177336024 @default.
• W1987349679 hasConceptScore W1987349679C202751555 @default.
• W1987349679 hasConceptScore W1987349679C203014093 @default.
• W1987349679 hasConceptScore W1987349679C2776090121 @default.
• W1987349679 hasConceptScore W1987349679C2776914184 @default.
• W1987349679 hasConceptScore W1987349679C502942594 @default.
• W1987349679 hasConceptScore W1987349679C522857546 @default.
• W1987349679 hasConceptScore W1987349679C54355233 @default.

• next