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- W1987355057 endingPage "39" @default.
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- W1987355057 abstract "A large number of potent and selective therapeutic agents, useful for the treatment of several diseases, have been isolated from natural sources. For example, the most active thrombin inhibitors are those secreted by the salivary glands of leeches. One peculiar feature of these agents is the lack of any significant inhibitory cross-reaction with other serine proteinases. Hence, the knowledge of the exact mechanism of action of these molecules provides the basis for the development of new and efficient synthetic drugs. For this reason, many studies have been undertaken on the structure–activity relationships of natural thrombin inhibitors, and a large amount of detailed information has been obtained by the crystal structures of these inhibitors when complexed with thrombin. In this paper, we review natural and synthetic multisite thrombin inhibitors, whose structural aspects have been determined in detail. We also report here the approach used by us to develop a new class of synthetic, multisite directed thrombin inhibitors, named hirunorms, designed to mimic the distinctive binding mode of hirudin. © 1999 John Wiley & Sons, Inc. Biopoly 51: 19–39, 1999" @default.
- W1987355057 created "2016-06-24" @default.
- W1987355057 creator A5006546192 @default.
- W1987355057 creator A5040072997 @default.
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- W1987355057 creator A5066156912 @default.
- W1987355057 creator A5080078552 @default.
- W1987355057 creator A5090517829 @default.
- W1987355057 date "1999-01-01" @default.
- W1987355057 modified "2023-10-16" @default.
- W1987355057 title "From natural to synthetic multisite thrombin inhibitors" @default.
- W1987355057 cites W1243769774 @default.
- W1987355057 cites W1479833274 @default.
- W1987355057 cites W1487224455 @default.
- W1987355057 cites W1490575535 @default.
- W1987355057 cites W1491436521 @default.
- W1987355057 cites W1517896461 @default.
- W1987355057 cites W1518197977 @default.
- W1987355057 cites W1536230526 @default.
- W1987355057 cites W1542079164 @default.
- W1987355057 cites W1545585691 @default.
- W1987355057 cites W1550185278 @default.
- W1987355057 cites W1551915691 @default.
- W1987355057 cites W1554928505 @default.
- W1987355057 cites W1555069122 @default.
- W1987355057 cites W1556558405 @default.
- W1987355057 cites W1560970554 @default.
- W1987355057 cites W1584647394 @default.
- W1987355057 cites W1587827058 @default.
- W1987355057 cites W1590237440 @default.
- W1987355057 cites W1591408368 @default.
- W1987355057 cites W1612882579 @default.
- W1987355057 cites W171420448 @default.
- W1987355057 cites W1814033164 @default.
- W1987355057 cites W1820009712 @default.
- W1987355057 cites W1878851182 @default.
- W1987355057 cites W1888945488 @default.
- W1987355057 cites W1891400877 @default.
- W1987355057 cites W1968506982 @default.
- W1987355057 cites W1968603196 @default.
- W1987355057 cites W1968797532 @default.
- W1987355057 cites W1968875893 @default.
- W1987355057 cites W1973441878 @default.
- W1987355057 cites W1974052300 @default.
- W1987355057 cites W1977389729 @default.
- W1987355057 cites W1978275166 @default.
- W1987355057 cites W1978359974 @default.
- W1987355057 cites W1981330323 @default.
- W1987355057 cites W1985469117 @default.
- W1987355057 cites W1986017909 @default.
- W1987355057 cites W1986457975 @default.
- W1987355057 cites W1986894628 @default.
- W1987355057 cites W1989361323 @default.
- W1987355057 cites W1989818029 @default.
- W1987355057 cites W1996123781 @default.
- W1987355057 cites W1996729024 @default.
- W1987355057 cites W2001790577 @default.
- W1987355057 cites W2003409814 @default.
- W1987355057 cites W2003892496 @default.
- W1987355057 cites W2003978987 @default.
- W1987355057 cites W2006876120 @default.
- W1987355057 cites W2008025366 @default.
- W1987355057 cites W2009420807 @default.
- W1987355057 cites W2009895546 @default.
- W1987355057 cites W2011214542 @default.
- W1987355057 cites W2012324791 @default.
- W1987355057 cites W2013547341 @default.
- W1987355057 cites W2018218229 @default.
- W1987355057 cites W2019338799 @default.
- W1987355057 cites W2021288696 @default.
- W1987355057 cites W2021514673 @default.
- W1987355057 cites W2028126372 @default.
- W1987355057 cites W2030831704 @default.
- W1987355057 cites W2031350447 @default.
- W1987355057 cites W2033797639 @default.
- W1987355057 cites W2035126782 @default.
- W1987355057 cites W2035307463 @default.
- W1987355057 cites W2035567217 @default.
- W1987355057 cites W2039906633 @default.
- W1987355057 cites W2040356924 @default.
- W1987355057 cites W2043526402 @default.
- W1987355057 cites W2043582950 @default.
- W1987355057 cites W2046939549 @default.
- W1987355057 cites W2048365785 @default.
- W1987355057 cites W2053215814 @default.
- W1987355057 cites W2054900177 @default.
- W1987355057 cites W2058693233 @default.
- W1987355057 cites W2060135725 @default.
- W1987355057 cites W2060297306 @default.
- W1987355057 cites W2061071120 @default.
- W1987355057 cites W2063683800 @default.
- W1987355057 cites W2067327367 @default.
- W1987355057 cites W2068475410 @default.
- W1987355057 cites W2069406655 @default.
- W1987355057 cites W2070887929 @default.
- W1987355057 cites W2072665488 @default.
- W1987355057 cites W2073624461 @default.
- W1987355057 cites W2075620058 @default.