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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987357809> ?p ?o ?g. }

• W1987357809 abstract "We studied the direct effects of PGE2, often produced at high levels by mammary tumours, on three human breast cancer cell lines diversely advanced in malignancy regarding differentiation and tumorigenicity in nude mice. We evaluated PGE2 effect on cell growth, PGE2 receptor level and functionality. Our results show that PGE2 induces cAMP accumulation and inhibits the growth of the most differentiated breast cancer cells. We also demonstrate that loss and probably dysfunction of PGE2 receptors is related to an advanced tumorigenic phenotype of the cells. Thus, it seems that during progression of breast cancer, the cell growth escapes from control by PGE2. Nevertheless, it is possible to control the growth of advanced breast cancer cells in vitro by direct induction of intracellular cAMP accumulation." @default.
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• W1987357809 date "1995-06-01" @default.
• W1987357809 modified "2023-09-25" @default.
• W1987357809 title "Alteration of prostaglandin E receptors in advanced breast tumour cell lines" @default.
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• W1987357809 doi "https://doi.org/10.1016/0303-7207(95)03572-o" @default.
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