FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987368432> ?p ?o ?g. }

• W1987368432 endingPage "878" @default.
• W1987368432 startingPage "873" @default.
• W1987368432 abstract "Abstract Background Erectile dysfunction (ED) in diabetes is related to autonomic neuropathy and endothelial dysfunction. We studied the relative importance of these factors in diabetic and non‐diabetic men with ED and determined if they predict responses to treatment with sildenafil. Methods Thirty‐three men, aged 35–65 years, with ED (20 diabetic, 13 non‐diabetic), 15 of whom were sildenafil responders and 18 non‐responders, were compared with 30 age and risk‐matched control subjects (15 diabetic, 15 non‐diabetic). Subjects with ED completed the International Index of Erectile Function (IIEF) questionnaire. Endothelial function was assessed by changes in brachio‐radial and femoro‐tibial arterial pulse‐wave velocity (pulse‐wave velocity) during reactive hyperaemia, expressed as percentage endothelium‐dependent dilatation. Autonomic function was assessed by heart rate variation during expiration and inspiration (E/I ratio) and during the valsalva manoeuvre. Results The respective changes in pulse‐wave velocity, in the arm and leg [mean ( sd )] were 0.71 (6.5)% and 3.5 (6.4)% in the impotent diabetic men, 0.7 (7.6)% and 2.4 (5.9)% in the non‐diabetic impotent men, −0.68 (5.7)% and −1.31 (7.2)% in the non‐impotent diabetic men and 7.7 (3.7)% and 7.6 (3.4)% in the control subjects. There was a significant interaction between ED and diabetic status such that there was significantly impaired vascular response in the diabetic group (both with and without ED) and in the non‐diabetic group with ED compared with the non‐diabetic control group ( P = 0.01 and P = 0.001 for brachio‐radial and femoro‐tibial measures, respectively). The E/I ratios of the diabetic men were significantly lower than those of the control subjects [1.17 (0.14) vs. 1.33 (0.16), P < 0.02), but there were no differences in the measures of autonomic neuropathy between the groups with ED and those with normal erectile function. Amongst diabetic men, the initial IIEF scores (maximum score 30, low score indicates more severe ED) were significantly higher in sildenafil‐responders than non‐responders [16.3 (8.4), vs. 6.8 (7 1), P < 0.02]. The rate of sildenafil response was not significantly affected by the measures of endothelial or autonomic function. Conclusions ED in both diabetic and non‐diabetic men is characterized by marked endothelial dysfunction in comparison with non‐diabetic control subjects. Response to sildenafil is not predicted by either endothelial function or autonomic function, but in diabetic men appears to be related to the initial degree of erectile dysfunction." @default.
• W1987368432 created "2016-06-24" @default.
• W1987368432 creator A5008354191 @default.
• W1987368432 creator A5030834308 @default.
• W1987368432 creator A5057707172 @default.
• W1987368432 creator A5060124799 @default.
• W1987368432 creator A5069296368 @default.
• W1987368432 creator A5080249819 @default.
• W1987368432 date "2006-05-25" @default.
• W1987368432 modified "2023-10-11" @default.
• W1987368432 title "The role of endothelial dysfunction in the pathophysiology of erectile dysfunction in diabetes and in determining response to treatment" @default.
• W1987368432 cites W1546689954 @default.
• W1987368432 cites W1578825445 @default.
• W1987368432 cites W1978904465 @default.
• W1987368432 cites W1980445357 @default.
• W1987368432 cites W1999051792 @default.
• W1987368432 cites W2012365138 @default.
• W1987368432 cites W2016654529 @default.
• W1987368432 cites W2019666885 @default.
• W1987368432 cites W2032974881 @default.
• W1987368432 cites W2035107871 @default.
• W1987368432 cites W2044634951 @default.
• W1987368432 cites W2044810125 @default.
• W1987368432 cites W2052518051 @default.
• W1987368432 cites W2056147576 @default.
• W1987368432 cites W2057116025 @default.
• W1987368432 cites W2060339082 @default.
• W1987368432 cites W2062855686 @default.
• W1987368432 cites W2062907730 @default.
• W1987368432 cites W2063506869 @default.
• W1987368432 cites W2080907400 @default.
• W1987368432 cites W2086240335 @default.
• W1987368432 cites W2093349952 @default.
• W1987368432 cites W2138969187 @default.
• W1987368432 cites W2145394555 @default.
• W1987368432 cites W2158368439 @default.
• W1987368432 cites W2287760080 @default.
• W1987368432 cites W2922351673 @default.
• W1987368432 cites W4254029756 @default.
• W1987368432 doi "https://doi.org/10.1111/j.1464-5491.2006.01911.x" @default.
• W1987368432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16911625" @default.
• W1987368432 hasPublicationYear "2006" @default.
• W1987368432 type Work @default.
• W1987368432 sameAs 1987368432 @default.
• W1987368432 citedByCount "50" @default.
• W1987368432 countsByYear W19873684322012 @default.
• W1987368432 countsByYear W19873684322013 @default.
• W1987368432 countsByYear W19873684322014 @default.
• W1987368432 countsByYear W19873684322015 @default.
• W1987368432 countsByYear W19873684322016 @default.
• W1987368432 countsByYear W19873684322017 @default.
• W1987368432 countsByYear W19873684322018 @default.
• W1987368432 countsByYear W19873684322021 @default.
• W1987368432 countsByYear W19873684322022 @default.
• W1987368432 crossrefType "journal-article" @default.
• W1987368432 hasAuthorship W1987368432A5008354191 @default.
• W1987368432 hasAuthorship W1987368432A5030834308 @default.
• W1987368432 hasAuthorship W1987368432A5057707172 @default.
• W1987368432 hasAuthorship W1987368432A5060124799 @default.
• W1987368432 hasAuthorship W1987368432A5069296368 @default.
• W1987368432 hasAuthorship W1987368432A5080249819 @default.
• W1987368432 hasConcept C10162356 @default.
• W1987368432 hasConcept C126322002 @default.
• W1987368432 hasConcept C134018914 @default.
• W1987368432 hasConcept C158846371 @default.
• W1987368432 hasConcept C164705383 @default.
• W1987368432 hasConcept C2776768464 @default.
• W1987368432 hasConcept C2777691872 @default.
• W1987368432 hasConcept C2778319312 @default.
• W1987368432 hasConcept C2779929075 @default.
• W1987368432 hasConcept C2780972559 @default.
• W1987368432 hasConcept C555293320 @default.
• W1987368432 hasConcept C71924100 @default.
• W1987368432 hasConcept C84393581 @default.
• W1987368432 hasConceptScore W1987368432C10162356 @default.
• W1987368432 hasConceptScore W1987368432C126322002 @default.
• W1987368432 hasConceptScore W1987368432C134018914 @default.
• W1987368432 hasConceptScore W1987368432C158846371 @default.
• W1987368432 hasConceptScore W1987368432C164705383 @default.
• W1987368432 hasConceptScore W1987368432C2776768464 @default.
• W1987368432 hasConceptScore W1987368432C2777691872 @default.
• W1987368432 hasConceptScore W1987368432C2778319312 @default.
• W1987368432 hasConceptScore W1987368432C2779929075 @default.
• W1987368432 hasConceptScore W1987368432C2780972559 @default.
• W1987368432 hasConceptScore W1987368432C555293320 @default.
• W1987368432 hasConceptScore W1987368432C71924100 @default.
• W1987368432 hasConceptScore W1987368432C84393581 @default.
• W1987368432 hasIssue "8" @default.
• W1987368432 hasLocation W19873684321 @default.
• W1987368432 hasLocation W19873684322 @default.
• W1987368432 hasOpenAccess W1987368432 @default.
• W1987368432 hasPrimaryLocation W19873684321 @default.
• W1987368432 hasRelatedWork W1779484613 @default.
• W1987368432 hasRelatedWork W1987273611 @default.
• W1987368432 hasRelatedWork W2007827894 @default.
• W1987368432 hasRelatedWork W2015896558 @default.
• W1987368432 hasRelatedWork W2038129812 @default.
• W1987368432 hasRelatedWork W2073112127 @default.

• next