FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987369972> ?p ?o ?g. }

• W1987369972 endingPage "361" @default.
• W1987369972 startingPage "353" @default.
• W1987369972 abstract "Previous studies from this laboratory have demonstrated that a COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol (2-AG), inhibits IL-2 secretion in activated T cells through PPARγ activation independent of the cannabinoid receptors, CB1/CB2. Because numerous cyclooxygenase (COX) products have been shown to activate PPARγ, the primary purpose of the present studies was to determine the role of COX metabolism in the inhibition of IL-2 secretion by 2-AG. Pretreatment with nonselective and COX-2-specific inhibitors completely abrogated 2-AG-mediated suppression of IL-2 secretion. In contrast, pretreatment with COX-1-specific inhibitors had no effect upon 2-AG-mediated inhibition of IL-2 secretion. Interestingly, the current studies also demonstrate that while the potency of 2-AG is comparable between human Jurkat T cells and murine splenocytes, anandamide (AEA) is markedly more potent in suppressing IL-2 production in Jurkat T cells compared to murine splenocytes. Additionally, the present studies also demonstrate that COX-2 protein is readily detectable in resting Jurkat T cells, which is in contrast to resting murine splenocytes in which COX-2 protein is virtually undetectable. Furthermore, COX-2 protein and mRNA levels are significantly increased over basal levels by 2 h following activation of Jurkat cells, whereas increases in COX-2 protein in murine splenocytes are not observed until 4 h after cellular activation. These studies suggest that the potency of AEA in the suppression of IL-2 secretion may correlate with COX-2 protein levels in different T cell models. The present studies are also significant in that they demonstrate 2-AG-mediated inhibition of IL-2 secretion is dependent upon COX-2 metabolism." @default.
• W1987369972 created "2016-06-24" @default.
• W1987369972 creator A5003836269 @default.
• W1987369972 creator A5020366031 @default.
• W1987369972 creator A5050290290 @default.
• W1987369972 creator A5055298886 @default.
• W1987369972 date "2008-08-01" @default.
• W1987369972 modified "2023-10-12" @default.
• W1987369972 title "A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells" @default.
• W1987369972 cites W1525772448 @default.
• W1987369972 cites W1633340712 @default.
• W1987369972 cites W1964548196 @default.
• W1987369972 cites W1966149760 @default.
• W1987369972 cites W1968505851 @default.
• W1987369972 cites W1971860422 @default.
• W1987369972 cites W1973909017 @default.
• W1987369972 cites W1978394922 @default.
• W1987369972 cites W2002201669 @default.
• W1987369972 cites W2003594380 @default.
• W1987369972 cites W2005674716 @default.
• W1987369972 cites W2006730284 @default.
• W1987369972 cites W2007931918 @default.
• W1987369972 cites W2008617419 @default.
• W1987369972 cites W2020765066 @default.
• W1987369972 cites W2022077377 @default.
• W1987369972 cites W2024653583 @default.
• W1987369972 cites W2028025615 @default.
• W1987369972 cites W2031612442 @default.
• W1987369972 cites W2040565048 @default.
• W1987369972 cites W2049772907 @default.
• W1987369972 cites W2050717908 @default.
• W1987369972 cites W2059960512 @default.
• W1987369972 cites W2060288239 @default.
• W1987369972 cites W2067705047 @default.
• W1987369972 cites W2069396957 @default.
• W1987369972 cites W2072696221 @default.
• W1987369972 cites W2073597849 @default.
• W1987369972 cites W2077344563 @default.
• W1987369972 cites W2083694547 @default.
• W1987369972 cites W2086458197 @default.
• W1987369972 cites W2089573633 @default.
• W1987369972 cites W2091572888 @default.
• W1987369972 cites W2097251306 @default.
• W1987369972 cites W2101768385 @default.
• W1987369972 cites W2103617764 @default.
• W1987369972 cites W2114437978 @default.
• W1987369972 cites W2126853519 @default.
• W1987369972 cites W2128549678 @default.
• W1987369972 cites W2138438714 @default.
• W1987369972 cites W2152872852 @default.
• W1987369972 cites W2153004740 @default.
• W1987369972 cites W2159973565 @default.
• W1987369972 cites W2167451638 @default.
• W1987369972 cites W2470586538 @default.
• W1987369972 cites W4247315158 @default.
• W1987369972 doi "https://doi.org/10.1016/j.bcp.2008.05.005" @default.
• W1987369972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18571623" @default.
• W1987369972 hasPublicationYear "2008" @default.
• W1987369972 type Work @default.
• W1987369972 sameAs 1987369972 @default.
• W1987369972 citedByCount "36" @default.
• W1987369972 countsByYear W19873699722013 @default.
• W1987369972 countsByYear W19873699722014 @default.
• W1987369972 countsByYear W19873699722015 @default.
• W1987369972 countsByYear W19873699722016 @default.
• W1987369972 countsByYear W19873699722017 @default.
• W1987369972 countsByYear W19873699722019 @default.
• W1987369972 countsByYear W19873699722020 @default.
• W1987369972 countsByYear W19873699722021 @default.
• W1987369972 countsByYear W19873699722023 @default.
• W1987369972 crossrefType "journal-article" @default.
• W1987369972 hasAuthorship W1987369972A5003836269 @default.
• W1987369972 hasAuthorship W1987369972A5020366031 @default.
• W1987369972 hasAuthorship W1987369972A5050290290 @default.
• W1987369972 hasAuthorship W1987369972A5055298886 @default.
• W1987369972 hasConcept C148001335 @default.
• W1987369972 hasConcept C153911025 @default.
• W1987369972 hasConcept C16613235 @default.
• W1987369972 hasConcept C170493617 @default.
• W1987369972 hasConcept C179464577 @default.
• W1987369972 hasConcept C185592680 @default.
• W1987369972 hasConcept C203014093 @default.
• W1987369972 hasConcept C2776090121 @default.
• W1987369972 hasConcept C2776885963 @default.
• W1987369972 hasConcept C2777477808 @default.
• W1987369972 hasConcept C2780871563 @default.
• W1987369972 hasConcept C46721173 @default.
• W1987369972 hasConcept C49039625 @default.
• W1987369972 hasConcept C55493867 @default.
• W1987369972 hasConcept C86803240 @default.
• W1987369972 hasConcept C8891405 @default.
• W1987369972 hasConcept C95444343 @default.
• W1987369972 hasConceptScore W1987369972C148001335 @default.
• W1987369972 hasConceptScore W1987369972C153911025 @default.
• W1987369972 hasConceptScore W1987369972C16613235 @default.
• W1987369972 hasConceptScore W1987369972C170493617 @default.
• W1987369972 hasConceptScore W1987369972C179464577 @default.
• W1987369972 hasConceptScore W1987369972C185592680 @default.

• next