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• W1987374295 abstract "Lymphocytes are crucial in the pathogenesis of inflammatory bowel disease (IBD) and are an important target for drug development. Our aim was to verify whether 2 vitamin D derivatives, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and EB 1089, could induce cell apoptosis and affect cell–cell interaction by regulating adhesion molecule levels. Peripheral blood mononuclear cell (PBMC) proliferation was studied by [3H]thymidine incorporation and apoptosis was determined using an enzyme-linked immunosorbent assay (ELISA) kit. (Poly(ADP-ribose)polymerase (PARP) cleavage, caspase-3, and ICAM-1 protein levels were determined by Western blot analysis. Our results indicate that 1,25(OH)2D3 or EB 1089 or anti-TNF-α (infliximab) induce apoptosis in PBMC obtained from healthy subjects. In IBD patients apoptosis is induced by vitamin D derivatives and by anti-TNF-α only in CD patients. Caspase-3 activation and PARP cleavage are registered when PBMC were treated with vitamin D derivatives. ICAM-1 levels remarkably increase when PBMC was incubated with lipopolysaccharide (LPS) or TNF-α. The treatment with the vitamin D derivatives, alone or in combination with LPS or TNF-α, significantly decreases ICAM-1 levels both in healthy subjects and IBD patients. In HUVEC cocultured with PBMC, previously incubated with LPS or TNF-α associated with 1,25(OH)2D3, ICAM-1 levels decrease both in healthy subjects and IBD patients. 1,25(OH)2D3 and EB 1089 inhibit PBMC proliferation, induce apoptosis in PBMC of healthy subjects and IBD patients, and affect ICAM-1 expression on PBMC and on HUVEC cocultured with PBMC, suggesting that the ICAM-1 downregulation could provide a new target for controlling the recruitment of leukocytes at the sites of inflammation in IBD." @default.
• W1987374295 created "2016-06-24" @default.
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• W1987374295 date "2008-05-01" @default.
• W1987374295 modified "2023-10-10" @default.
• W1987374295 title "Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients" @default.
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• W1987374295 doi "https://doi.org/10.1002/ibd.20354" @default.
• W1987374295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18200516" @default.
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