FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987375061> ?p ?o ?g. }

• W1987375061 endingPage "132" @default.
• W1987375061 startingPage "122" @default.
• W1987375061 abstract "The bipotent liver progenitor cells, so called oval cells, may participate at the early stages of hepatocarcinogenesis induced by chemical carcinogens. Unlike in mature parenchymal cells, little is known about formation of DNA adducts and other genotoxic events in oval cells. In the present study, we employed spontaneously immortalized rat liver WB-F344 cell line, which is an established in vitro model of oval cells, in order to study genotoxic effects of selected carcinogenic polycyclic aromatic hydrocarbons (PAHs). With exception of dibenzo[a,l]pyrene, and partly also benzo[g]chrysene and benz[a]anthracene, all other PAHs under the study induced high levels of CYP1A1 and CYP1B1 mRNA. In contrast, we observed distinct genotoxic and cytotoxic potencies of PAHs. Dibenzo[a,l]pyrene, and to a lesser extent also benzo[a]pyrene, benzo[g]chrysene and dibenzo[a,e]pyrene, formed high levels of DNA adducts. This was accompanied with accumulation of Ser-15 phosphorylated form of p53 protein and induction of apoptosis. Contrary to that, benz[a]anthracene, chrysene, benzo[b]fluoranthene and dibenzo[a,h]anthracene induced only low amounts of DNA adducts formation and minimal apoptosis, without exerting significant effects on p53 phosphorylation. Finally, we studied effects of 2,4,3′,5′-tetramethoxystilbene and fluoranthene, inhibitors of CYP1B1 activity, which plays a central role in metabolic activation of dibenzo[a,l]pyrene. In a dose-dependent manner, both compounds inhibited apoptosis induced by dibenzo[a,l]pyrene, suggesting that it interferes with the metabolic activation of the latter one. The present data show that in model cell line sharing phenotypic properties with oval cells, PAHs can be efficiently metabolized to form ultimate genotoxic metabolites. Liver progenitor cells could be thus susceptible to this type of genotoxic insult, which makes WB-F344 cell line a useful tool for studies of genotoxic effects of organic contaminants in liver cells. Our results also suggest that, unlike in mature hepatocytes, CYP1B1 might be a primary enzyme responsible for formation of DNA adducts in liver progenitor cells." @default.
• W1987375061 created "2016-06-24" @default.
• W1987375061 creator A5006083281 @default.
• W1987375061 creator A5009870981 @default.
• W1987375061 creator A5036785854 @default.
• W1987375061 creator A5042219680 @default.
• W1987375061 creator A5059582565 @default.
• W1987375061 creator A5064376052 @default.
• W1987375061 creator A5064476445 @default.
• W1987375061 creator A5067207213 @default.
• W1987375061 date "2008-02-01" @default.
• W1987375061 modified "2023-10-16" @default.
• W1987375061 title "DNA adducts formation and induction of apoptosis in rat liver epithelial ‘stem-like’ cells exposed to carcinogenic polycyclic aromatic hydrocarbons" @default.
• W1987375061 cites W183310730 @default.
• W1987375061 cites W1965407474 @default.
• W1987375061 cites W1970983968 @default.
• W1987375061 cites W1972487225 @default.
• W1987375061 cites W1972921001 @default.
• W1987375061 cites W1976445136 @default.
• W1987375061 cites W1992836428 @default.
• W1987375061 cites W1996033279 @default.
• W1987375061 cites W1996381333 @default.
• W1987375061 cites W1998420703 @default.
• W1987375061 cites W2006635679 @default.
• W1987375061 cites W2011700305 @default.
• W1987375061 cites W2012772121 @default.
• W1987375061 cites W2017615436 @default.
• W1987375061 cites W2017896421 @default.
• W1987375061 cites W2018057558 @default.
• W1987375061 cites W2021319934 @default.
• W1987375061 cites W2022396677 @default.
• W1987375061 cites W2032875809 @default.
• W1987375061 cites W2035052349 @default.
• W1987375061 cites W2035538685 @default.
• W1987375061 cites W2046056065 @default.
• W1987375061 cites W2049084155 @default.
• W1987375061 cites W2060656945 @default.
• W1987375061 cites W2061778686 @default.
• W1987375061 cites W2068986290 @default.
• W1987375061 cites W2073871987 @default.
• W1987375061 cites W2078775914 @default.
• W1987375061 cites W2079518314 @default.
• W1987375061 cites W2081226879 @default.
• W1987375061 cites W2084223046 @default.
• W1987375061 cites W2085240387 @default.
• W1987375061 cites W2086206454 @default.
• W1987375061 cites W2101625418 @default.
• W1987375061 cites W2102467381 @default.
• W1987375061 cites W2103416708 @default.
• W1987375061 cites W2107277218 @default.
• W1987375061 cites W2107320516 @default.
• W1987375061 cites W2108170421 @default.
• W1987375061 cites W2113357785 @default.
• W1987375061 cites W2116136869 @default.
• W1987375061 cites W2117335756 @default.
• W1987375061 cites W2122613732 @default.
• W1987375061 cites W2122939933 @default.
• W1987375061 cites W2128329009 @default.
• W1987375061 cites W2128442121 @default.
• W1987375061 cites W2131664502 @default.
• W1987375061 cites W2136979398 @default.
• W1987375061 cites W2147364311 @default.
• W1987375061 cites W2151648368 @default.
• W1987375061 cites W2152037335 @default.
• W1987375061 cites W2153089799 @default.
• W1987375061 cites W2156947001 @default.
• W1987375061 cites W2314811539 @default.
• W1987375061 cites W4239384318 @default.
• W1987375061 doi "https://doi.org/10.1016/j.mrfmmm.2007.09.004" @default.
• W1987375061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17961608" @default.
• W1987375061 hasPublicationYear "2008" @default.
• W1987375061 type Work @default.
• W1987375061 sameAs 1987375061 @default.
• W1987375061 citedByCount "57" @default.
• W1987375061 countsByYear W19873750612012 @default.
• W1987375061 countsByYear W19873750612013 @default.
• W1987375061 countsByYear W19873750612014 @default.
• W1987375061 countsByYear W19873750612015 @default.
• W1987375061 countsByYear W19873750612016 @default.
• W1987375061 countsByYear W19873750612017 @default.
• W1987375061 countsByYear W19873750612019 @default.
• W1987375061 countsByYear W19873750612020 @default.
• W1987375061 countsByYear W19873750612021 @default.
• W1987375061 countsByYear W19873750612022 @default.
• W1987375061 countsByYear W19873750612023 @default.
• W1987375061 crossrefType "journal-article" @default.
• W1987375061 hasAuthorship W1987375061A5006083281 @default.
• W1987375061 hasAuthorship W1987375061A5009870981 @default.
• W1987375061 hasAuthorship W1987375061A5036785854 @default.
• W1987375061 hasAuthorship W1987375061A5042219680 @default.
• W1987375061 hasAuthorship W1987375061A5059582565 @default.
• W1987375061 hasAuthorship W1987375061A5064376052 @default.
• W1987375061 hasAuthorship W1987375061A5064476445 @default.
• W1987375061 hasAuthorship W1987375061A5067207213 @default.
• W1987375061 hasConcept C107872376 @default.
• W1987375061 hasConcept C114246631 @default.
• W1987375061 hasConcept C143425029 @default.
• W1987375061 hasConcept C153911025 @default.

• next