FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987386460> ?p ?o ?g. }

• W1987386460 abstract "The incomplete release of Endostar from PLGA microspheres was observed in our previous study. In the present study, we focused on the effect of medium-chain triglycerides (MCT) on the in vitro/in vivo release behavior of Endostar encapsulated PLGA microspheres, which were prepared by a water-in-oil-in-water (W/O/W) double-emulsion method with or without MCT. The in vitro accumulated release of Endostar from microspheres co-encapsulated with 30% MCT was found to be 79.04% after a 30-day incubation period in PBS (pH 7.4) at 37 degrees C. However, the accumulated release of Endostar from MCT-free microspheres was found to be only 32.22%. Pouches containing Endostar encapsulated PLGA microspheres were implanted subcutaneously in rats. The effect of MCT on the in vivo release showed a similar trend to the in vitro release. After 30 days, only 9.87% of the total encapsulated Endostar was retained in microspheres co-encapsulated with 30% MCT, while 42.25% of Endostar was retained in MCT-free microspheres. The co-encapsulation of MCT provided the microspheres with a porous surface, which significantly improved the in vitro/in vivo release of Endostar from PLGA microspheres. In addition, in vitro experiments showed that MCT co-encapsulated PLGA microspheres had more inter-connected pores, faster degradation of PLGA, and faster swelling of microspheres, which helped to explain the mechanism of the effect of MCT on improving the release of Endostar from PLGA microspheres." @default.
• W1987386460 created "2016-06-24" @default.
• W1987386460 creator A5001099948 @default.
• W1987386460 creator A5015169877 @default.
• W1987386460 creator A5046416352 @default.
• W1987386460 creator A5068884694 @default.
• W1987386460 creator A5072778953 @default.
• W1987386460 creator A5072861069 @default.
• W1987386460 creator A5079618691 @default.
• W1987386460 date "2010-09-01" @default.
• W1987386460 modified "2023-09-26" @default.
• W1987386460 title "Effect of medium-chain triglycerides on the release behavior of Endostar® encapsulated PLGA microspheres" @default.
• W1987386460 cites W1539664785 @default.
• W1987386460 cites W1920456787 @default.
• W1987386460 cites W1980258733 @default.
• W1987386460 cites W1983007289 @default.
• W1987386460 cites W1983052470 @default.
• W1987386460 cites W1985019144 @default.
• W1987386460 cites W1987270443 @default.
• W1987386460 cites W1995482634 @default.
• W1987386460 cites W2001378344 @default.
• W1987386460 cites W2003742048 @default.
• W1987386460 cites W2007635182 @default.
• W1987386460 cites W2011594076 @default.
• W1987386460 cites W2011787985 @default.
• W1987386460 cites W2014546288 @default.
• W1987386460 cites W2037311180 @default.
• W1987386460 cites W2041116703 @default.
• W1987386460 cites W2054373549 @default.
• W1987386460 cites W2058785116 @default.
• W1987386460 cites W2061648748 @default.
• W1987386460 cites W2063284417 @default.
• W1987386460 cites W2065439702 @default.
• W1987386460 cites W2066202831 @default.
• W1987386460 cites W2069499547 @default.
• W1987386460 cites W2085396553 @default.
• W1987386460 cites W2088620810 @default.
• W1987386460 cites W2090939410 @default.
• W1987386460 cites W2108786375 @default.
• W1987386460 cites W2131756454 @default.
• W1987386460 cites W2131798870 @default.
• W1987386460 cites W2140879835 @default.
• W1987386460 cites W2339671032 @default.
• W1987386460 cites W2492129060 @default.
• W1987386460 cites W339969875 @default.
• W1987386460 cites W2003632783 @default.
• W1987386460 doi "https://doi.org/10.1016/j.ijpharm.2010.07.018" @default.
• W1987386460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20655370" @default.
• W1987386460 hasPublicationYear "2010" @default.
• W1987386460 type Work @default.
• W1987386460 sameAs 1987386460 @default.
• W1987386460 citedByCount "6" @default.
• W1987386460 countsByYear W19873864602013 @default.
• W1987386460 countsByYear W19873864602015 @default.
• W1987386460 countsByYear W19873864602016 @default.
• W1987386460 countsByYear W19873864602018 @default.
• W1987386460 crossrefType "journal-article" @default.
• W1987386460 hasAuthorship W1987386460A5001099948 @default.
• W1987386460 hasAuthorship W1987386460A5015169877 @default.
• W1987386460 hasAuthorship W1987386460A5046416352 @default.
• W1987386460 hasAuthorship W1987386460A5068884694 @default.
• W1987386460 hasAuthorship W1987386460A5072778953 @default.
• W1987386460 hasAuthorship W1987386460A5072861069 @default.
• W1987386460 hasAuthorship W1987386460A5079618691 @default.
• W1987386460 hasConcept C127413603 @default.
• W1987386460 hasConcept C13965031 @default.
• W1987386460 hasConcept C150903083 @default.
• W1987386460 hasConcept C163588942 @default.
• W1987386460 hasConcept C171250308 @default.
• W1987386460 hasConcept C185592680 @default.
• W1987386460 hasConcept C189942447 @default.
• W1987386460 hasConcept C192562407 @default.
• W1987386460 hasConcept C202751555 @default.
• W1987386460 hasConcept C207001950 @default.
• W1987386460 hasConcept C2778123984 @default.
• W1987386460 hasConcept C2778540859 @default.
• W1987386460 hasConcept C2780165375 @default.
• W1987386460 hasConcept C42360764 @default.
• W1987386460 hasConcept C43617362 @default.
• W1987386460 hasConcept C55493867 @default.
• W1987386460 hasConcept C77281830 @default.
• W1987386460 hasConcept C86803240 @default.
• W1987386460 hasConceptScore W1987386460C127413603 @default.
• W1987386460 hasConceptScore W1987386460C13965031 @default.
• W1987386460 hasConceptScore W1987386460C150903083 @default.
• W1987386460 hasConceptScore W1987386460C163588942 @default.
• W1987386460 hasConceptScore W1987386460C171250308 @default.
• W1987386460 hasConceptScore W1987386460C185592680 @default.
• W1987386460 hasConceptScore W1987386460C189942447 @default.
• W1987386460 hasConceptScore W1987386460C192562407 @default.
• W1987386460 hasConceptScore W1987386460C202751555 @default.
• W1987386460 hasConceptScore W1987386460C207001950 @default.
• W1987386460 hasConceptScore W1987386460C2778123984 @default.
• W1987386460 hasConceptScore W1987386460C2778540859 @default.
• W1987386460 hasConceptScore W1987386460C2780165375 @default.
• W1987386460 hasConceptScore W1987386460C42360764 @default.
• W1987386460 hasConceptScore W1987386460C43617362 @default.
• W1987386460 hasConceptScore W1987386460C55493867 @default.
• W1987386460 hasConceptScore W1987386460C77281830 @default.
• W1987386460 hasConceptScore W1987386460C86803240 @default.

• next