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- W1987388763 abstract "Aims: The liver-secreted peptide hepcidin is the key iron hormone at the systemic level. It decreases duodenal iron absorption and iron release by macrophages during conditions of excess iron by blocking the iron exporter ferroportin. In addition, IL-6 mediated upregulation of hepcidin during inflammation is the major mechanism of the so-called „anemia of chronic disease“. We here identify H2O2 which is co-released by inflammatory cells as potent transcriptional activator of hepcidin independent of upstream regulators IL-6 and BMP6." @default.
- W1987388763 created "2016-06-24" @default.
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- W1987388763 date "2010-08-01" @default.
- W1987388763 modified "2023-09-26" @default.
- W1987388763 title "H2O2 rapidly activates the systemic iron hormone hepcidin independent of the IL-6/BMP6 network" @default.
- W1987388763 doi "https://doi.org/10.1055/s-0030-1263852" @default.
- W1987388763 hasPublicationYear "2010" @default.
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